Breaking barriers: The potential of nanosystems in antituberculosis therapy

Author(s)

Canales, Christian S. Carnero ; Cazorla, Jessica Ingrid Marquez ; Cazorla, Renzo Marianito Marquez ; Roque-Borda, Cesar Augusto ; Polinario, Giulia ; Banda, Rufo A. Figueroa ; Sabio, Rafael Miguel ; Chorilli, Marlus ; Santos, Helder A. ; Pavan, Fernando Rogerio

• Document type: Journal article
• Source: BIOACTIVE MATERIALS; v. 39, p. 29-pg., 2024-09-01.

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a significant threat to global health. The resilience of TB is amplified by a myriad of physical, biological, and biopharmaceutical barriers that challenge conventional therapeutic approaches. This review navigates the intricate landscape of TB treatment, from the stealth of latent infections and the strength of granuloma formations to the daunting specters of drug resistance and altered gene expression. Amidst these challenges, traditional therapies often fail, contending with inconsistent bioavailability, prolonged treatment regimens, and socioeconomic burdens. Nanoscale Drug Delivery Systems (NDDSs) emerge as a promising beacon, ready to overcome these barriers, offering better drug targeting and improved patient adherence. Through a critical approach, we evaluate a spectrum of nanosystems and their efficacy against MTB both in vitro and in vivo. This review advocates for the intensification of research in NDDSs, heralding their potential to reshape the contours of global TB treatment strategies. (AU)

• FAPESP's process: 20/16573-3 - In vitro and in vivo studies of antimicrobial peptide B1CTcu5 analogs encapsulated in colon-specific microparticles against Mycobacterium tuberculosis
• Grantee: Cesar Augusto Roque Borda
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/02661-3 - Evaluation of cetuximab-modified porous silicon nanoparticles as docetaxel carrier to prostate cancer treatment
• Grantee: Rafael Miguel Sábio
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants