| Full text | |
| Author(s): |
Facure, Murilo H. M.
;
Gahramanova, Gulnaz
;
Zhang, Danzhen
;
Zhang, Teng
;
Shuck, Christopher E.
;
Mercante, Luiza A.
;
Correa, Daniel S.
;
Gogotsi, Yury
Total Authors: 8
|
| Document type: | Journal article |
| Source: | BIOSENSORS & BIOELECTRONICS; v. 262, p. 7-pg., 2024-07-01. |
| Abstract | |
Neurotransmitters (NTs) are molecules produced by neurons that act as the body's chemical messengers. Their abnormal levels in the human system have been associated with many disorders and neurodegenerative diseases, which makes the monitoring of NTs fundamentally important. Specifically for clinical analysis and understanding of brain behavior, simultaneous detection of NTs at low levels quickly and reliably is imperative for disease prevention and early diagnosis. However, the methods currently employed are usually invasive or inappropriate for multiple NTs detection. Herein, we developed a MXene-based impedimetric electronic tongue (e-tongue) for sensitive NT monitoring, using Nb2C, Nb4C3, Mo2C, and Mo2Ti2C3 MXenes as sensing units of the e-tongue, and Principal Component Analysis (PCA) as the data treatment method. The high specific surface area, distinct electrical properties, and chemical stability of the MXenes gave rise to high sensitivity and good reproducibility of the sensor array toward NT detection. Specifically, the e-tongue detected and differentiated multiple NTs (acetylcholine, dopamine, glycine, glutamate, histamine, and tyrosine) at concentrations as low as 1 nmol L-1 and quantified NTs present in a mixture. Besides, analyses performed with interferents and actual samples confirmed the system's potential to be used in clinical diagnostics. The results demonstrate that the MXene-based e-tongue is a suitable, rapid, and simple method for NT monitoring with high accuracy and sensitivity. (AU) | |
| FAPESP's process: | 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis |
| Grantee: | Osvaldo Novais de Oliveira Junior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/11683-8 - Composites based on MXenes/graphene quantum dots: production, characterization, and application in chemical sensors |
| Grantee: | Murilo Henrique Moreira Facure |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 17/10582-8 - Production and characterization of graphene quantum dots and their application in chemical sensors |
| Grantee: | Murilo Henrique Moreira Facure |
| Support Opportunities: | Scholarships in Brazil - Doctorate |