Chitosan surface modification modulates the mucoadhesive, permeation and anti-angiogenic properties of gellan gum/bevacizumab nanoparticles

Author(s)

Carvalho, Suzana Goncalves ; Haddad, Felipe Falcao ; dos Santos, Aline Martins ; Scarim, Caue Benito ; Ferreira, Leonardo Miziara Barboza ; Meneguin, Andreia Bagliotti ; Chorilli, Marlus ; Gremiao, Maria Palmira Daflon

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 263, p. 9-pg., 2024-02-19.

Abstract

Bevacizumab (BVZ) was the first monoclonal antibody approved by the FDA and has shown an essential advance in the antitumor therapy of colorectal cancer (CRC), however, the systemic action of BVZ administered intravenously can trigger several adverse effects. The working hypothesis of the study was to promote the modulation of the mucoadhesion properties and permeability of the BVZ through the formation of nanoparticles (NPs) with gellan gum (GG) with subsequent surface modification with chitosan (CS). NPs comprising BVZ and GG were synthesized through polyelectrolyte complexation, yielding spherical nanosized particles with an average diameter of 264.0 +/- 2.75 nm and 314.0 +/- 0.01 nm, polydispersity index of 0.182 +/- 0.01 e 0.288 +/- 0.01, and encapsulation efficiency of 29.36 +/- 0.67 e 60.35 +/- 0.27 mV, for NPs without (NP_BVZ) and with surface modification (NP_BVZ + CS). The results showed a good ability of nanoparticles with surface modification to modulate the NPs biological properties. (AU)

• FAPESP's process: 22/14075-1 - Multifunctional systems based on polysaccharides for colon-specific release of post-biotics and their potential for application in the treatment and prevention of inflammatory bowel diseases
• Grantee: Suzana Gonçalves Carvalho
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/10761-5 - Multifunctional systems for the specific colonoscopy of bevacizumab for the treatment of Colorectal Cancer
• Grantee: Suzana Gonçalves Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants