Multifunctional polymeric systems based on microparticles containing nanocarriers for camptothecin colonic release

• Grant number: 17/26349-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): May 01, 2018
• Effective date (End): October 10, 2021
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Maria Palmira Daflon Gremião
• Grantee: Fernanda Isadora Boni
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The design of a multifunctional polymeric system based on nanocarriers carried in microparticles for the oral administration represents a rational and promising strategy for the target of antitumor drugs to the colon. The proposed system in this project was drawn from the association of polymers previously studied by our research group and by the candidate, which add favourable properties to the desired performance, such as mucoadhesiveness, pH-responsive solubility and swelling, specific enzymatic degradability and potential of for drug target to tumour cells. Gellan gum/pectin microparticles or gellan gum/starch will be obtained and the critical attributes for their potential application will be determined. Nanoparticles based on chitosan and hydroxypropylmethylcellulose phthalate with or without hyaluronic acid and the drug camptothecin will be developed, evaluated and incorporated into the microparticles, which will be characterized according to size, shape, morphology as well as their structural characteristics. The critical attributes for the performance of the multifunctional system such as mucoadhesiveness and mucopenetration, in vitro drug release profile, in vitro intestinal permeability and antiangiogenic activity, will be evaluated. The set of data obtained will not only allow to the determination of the system potential for the application in the colorectal cancer treatment, but also contribute to the understanding of the mechanisms involved in the formation and interaction of the system in the biointerface. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BONI, FERNANDA ISADORA; FERREIRA, NATALIA NORONHA; RODERO, CAMILA FERNANDA; LEA, ALINE FRANCIANE; CURY, BEATRIZ STRINGHETTI FERREIRA; GREMIA, MARIA PALMIRA DAFLON. Multilayered polymer coating modulates mucoadhesive and biological properties of camptothecin-loaded lipid nanocapsules. International Journal of Pharmaceutics, v. 635, p. 8-pg., 2023-03-06. (17/26349-0)

BONI, FERNANDA ISADORA; CURY, BEATRIZ S. F.; FERREIRA, NATALIA NORONHA; GREMIAO, MARIA PALMIRA DAFLON. Ionic Cross-Linking as a Strategy to Modulate the Properties of Oral Mucoadhesive Microparticles Based on Polysaccharide Blends. PHARMACEUTICS, v. 13, n. 3, MAR 2021. (17/26349-0)

PEDREIRO, LILIANE NEVES; BONI, FERNANDA ISADORA; FERREIRA CURY, BEATRIZ STRINGHETTI; FERREIRA, NATALIA NORONHA; DAFLON GREMIAO, MARIA PALMIRA. Solid dispersions based on chitosan/hypromellose phthalate blends to modulate pharmaceutical properties of zidovudine. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, v. 27, n. 5, p. 10-pg., 2022-07-18. (13/01670-0, 19/25645-0, 17/26349-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BONI, Fernanda Isadora. Sistemas poliméricos multifuncionais baseados em micropartículas contendo nanocarreadores para liberação colônica da camptotecina. 2022. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.