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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection of Psychoactive N,N-Dimethyltryptaniine Alkaloid Based on Surface-Enhanced Raman Scattering Using Gold Nanostars in Flexible Inkjet-Printing Paper Substrates

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Author(s):
Edison Huertas-Montoya [1] ; Anerise de Barros [2] ; Lucas M. F. Oliveira [3] ; Paola A. Caro Aponte [4] ; Alexandre L. R. Oliveira [5] ; Flavio M. Shimizu ; Alessandra Sussulini [7] ; Fernando A. Sigoli [8] ; Italo O. Mazali [9]
Total Authors: 9
Affiliation:
[1] Universidade Estadual de Campinas. Instituto de Química. Laboratório de Materiais Funcionais - Brasil
[2] Universidade Estadual de Campinas. Instituto de Química. Laboratório de Materiais Funcionais - Brasil
[3] Universidade Estadual de Campinas. Instituto de Química. Laboratório de Materiais Funcionais - Brasil
[4] Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Regeneração Nervosa - Brasil
[5] Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Regeneração Nervosa - Brasil
[7] Universidade Estadual de Campinas. Instituto de Química. Laboratório de Bioanalítica e Ciências Ômicas Integradas - Brasil
[8] Universidade Estadual de Campinas. Instituto de Química. Laboratório de Materiais Funcionais - Brasil
[9] Universidade Estadual de Campinas. Instituto de Química. Laboratório de Materiais Funcionais - Brasil
Total Affiliations: 9
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 35, n. 12 2024-07-22.
Abstract

N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that, when combined with monoamine oxidase enzyme inhibitors in the hallucinogenic beverage commonly known as ayahuasca, surpasses most common orally administered psychoactive drugs. There is a growing interest in the therapeutic potential of DMT due to recent clinical data showing the improvement of cognitive deficits associated with depression and Alzheimer’s disease. The development of analytical methodology for the monitoring of concentrations of DMT molecules to control the appropriate dosage for their use is essential for the treatment of patients. For this, we propose a novel flexible inkjet-printed paper substrate based on Au nanostars as proof of concept for DMT detection by surface-enhanced Raman scattering (SERS). The substrate was applied to detect DMT in water as a first approach to more complex matrices like ayahuasca beverages or blood samples. The optimization and performance of SERS substrates with different print cycles indicate that one print is enough to achieve the great performance of the flexible paper substrates. The SERS analyses for DMT in different concentrations, 10-3 to 10-10 mol L-1, reveal a high sensitivity of the sensors with a silhouette coefficient of 0.84 obtained by principal component analysis (PCA) statistical projections. (AU)

FAPESP's process: 22/02893-1 - Eco-friendly methods of metallic nanoparticles synthesis for application in evaluating soybean plants growth in the presence of the nanoparticles
Grantee:Anerise de Barros
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 21/02754-9 - Neuroprotective effects of N, N-dimethyltryptamine and FGF-2 after ventral root avulsion and reimplantation with a heterologous fibrin biopolymer
Grantee:Paola Andrea Caro Aponte
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50906-9 - INCT 2014: in Functional Complex Materials
Grantee:Fernando Galembeck
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 22/11983-4 - Spectroscopy signal enhancement: nanomaterials, theory, and computer simulation
Grantee:Mauro Carlos Costa Ribeiro
Support Opportunities: Research Projects - Thematic Grants