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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, Characterization and Biocompatibility of Elastomeric Poly(L-co-D,L-lactic acid-co-Caprolactone)urethane for Biomedical Applications

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Author(s):
Carolini S. Brandolise [1] ; Bruna V. Quevedo [2] ; Jéssica Asami [3] ; Flavia Pedrini [4] ; Rodrigo César Gomes [5] ; Moema A. Hausen [6] ; Daniel Komatsu [7] ; Eliana A. R. Duek
Total Authors: 8
Affiliation:
[1] Universidade Federal de São Carlos. Programa de Pós-Graduação em Ciência dos Materiais - Brasil
[2] Universidade Federal de São Carlos. Programa de Pós-Graduação em Ciência dos Materiais - Brasil
[3] Universidade Estadual de Campinas. Faculdade de Engenharia Mecânica - Brasil
[4] Universidade Federal de São Carlos. Programa de Pós-Graduação em Biotecnologia e Monitoramento Ambiental - Brasil
[5] Universidade Federal de São Carlos. Programa de Pós-Graduação em Biotecnologia e Monitoramento Ambiental - Brasil
[6] Pontifícia Universidade Católica de São Paulo. Departamento de Cirurgia. Programa de Pós-Graduação em Biomateriais e Medicina Regenerativa - Brasil
[7] Pontifícia Universidade Católica de São Paulo. Departamento de Cirurgia. Programa de Pós-Graduação em Biomateriais e Medicina Regenerativa - Brasil
Total Affiliations: 8
Document type: Journal article
Source: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 27, 2024-10-14.
Abstract

A versatile nature of polyurethanes allows for the modification of thermal, mechanical, and chemical properties, making them promising candidates for medical applications. This study focuses on the synthesis, characterization, and biocompatibility evaluation of a novel poly (L-co-D,L-co-lactic acid-co-Caprolactone)urethane (PLDLA-PCL-PU) material derived from L-lactide, D,L-lactide, polycaprolactone-diol (PCL-diol) and 1,6-hexamethylene diisocyanate (HDI). This research performs a meticulous two-stage synthesis process, ultimately leading to the formation of PLDLA-PCL-PU through polymerization of the prepolymer (PP) and HDI. The confirmation of successful synthesis and the characterization of PLDLA-PCL-PU was done by FTIR-ATR, and 1H NMR. As evidenced by XRD, the amorphous nature of PLDLA reduces the degree of crystallinity in PLDLA-PCL-PU. Thermal decompositions, as well as the associated thermal events, were investigated using TGA and DSC. The biocompatibility of the material was evaluated using human mesenchymal stem cells. These assays reveal a notable enhancement in cell metabolic activity and proliferation when in contact with polyurethane membranes. By combining the properties of polyurethanes with the custom design of PLDLA-PCL-PU, this research strives to contribute with the advancement of biomaterials that promote tissue regeneration. (AU)

FAPESP's process: 23/17083-8 - Development and Evaluation of Injectable Bioactive Hydrogel Composed of Silk Fibroin, Puerarin and Reduced Graphene Oxide Directed for Post-Myocardial Infarction Therapy
Grantee:Bruna Vanessa Quevedo Miranda
Support Opportunities: Scholarships in Brazil - Doctorate