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Hybrid magnetic and antibacterial nanoparticles: synthesis, characterization and applications

Grant number: 18/02832-7
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2018
Effective date (End): June 28, 2020
Field of knowledge:Interdisciplinary Subjects
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Amedea Barozzi Seabra
Grantee:Joana Claudio Pieretti
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated scholarship(s):19/07766-5 - Blood compatibility of hybrid magnetic/silver nanoparticles coated with nitric oxide donor, BE.EP.MS


Recently, the preparation of hybrid nanostructured materials represents a promisor strategy in the development of new platforms to obtain versatile nanomaterials with different characteristics and functions in a single structure. Superparamagnetic iron oxide (Fe3O4) nanoparticles has been receiving huge attention in the last few years, due to its biomedical applications versatility such as diagnoses, magnetic resonance imaging, cancer treatment, controlled drug delivery, among others. Likewise, silver nanoparticles (Ag) show powerful antibacterial action and are employed in the food, textile, pharmaceutical and agricultural industries. In this context, this project aims the synthesis and characterization of Fe3O4/Ag, involving chemical and biogenic synthesis, being: (i) superparamagnetic and (ii) antibacterial. The application of an external magnetic field can also be used to remove these nanoparticles from the medium of interest, this action implies in the nanoparticles reuse in biomedical applications, as well on the proper removal from the environment. To improve nanoparticles antibacterial action, besides improving its aqueous dispersion and biocompatibility, the surface of the Fe3O4/Ag will be coated with chitosan, a natural biocompatible, biodegradable and antimicrobial polymer. Furthermore, the coating with chitosan nanoparticles enable the incorporation of nitric oxide donors, well known for its antibacterial properties. Therefore, this project includes the preparation of hybrid, magnetic and antimicrobial nanoparticles, using chemical and biogenic methods with great potential to biomedical applications. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GALLARDO-BENAVENTE, CARLA; CARRION, ORNELLA; TODD, JONATHAN D.; PIERETTI, JOANA C.; SEABRA, AMEDEA B.; DURAN, NELSON; RUBILAR, OLGA; PEREZ-DONOSO, JOSE M.; QUIROZ, ANDRES. Biosynthesis of CdS Quantum Dots Mediated by Volatile Sulfur Compounds Released by Antarctic Pseudomonas fragi. FRONTIERS IN MICROBIOLOGY, v. 10, AUG 13 2019. Web of Science Citations: 0.
ROLIM, WALLACE R.; PIERETTI, JOANA C.; RENO, DEBORA L. S.; LIMA, BRUNA A.; NASCIMENTO, MONICA H. M.; AMBROSIO, FELIPE N.; LOMBELLO, CHRISTIANE B.; BROCCHI, MARCELO; DE SOUZA, ANA CAROLINA S.; SEABRA, AMEDEA B. Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 6, p. 6589-6604, FEB 13 2019. Web of Science Citations: 5.

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