Hybrid magnetic and antibacterial nanoparticles: synthesis, characterization and applications

• Grant number: 18/02832-7
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): May 01, 2018
• Effective date (End): April 30, 2020
• Field of knowledge: Interdisciplinary Subjects
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Amedea Barozzi Seabra
• Grantee: Joana Claudio Pieretti
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated scholarship(s): 19/07766-5 - Blood compatibility of hybrid magnetic/silver nanoparticles coated with nitric oxide donor, BE.EP.MS

Abstract

Recently, the preparation of hybrid nanostructured materials represents a promisor strategy in the development of new platforms to obtain versatile nanomaterials with different characteristics and functions in a single structure. Superparamagnetic iron oxide (Fe3O4) nanoparticles has been receiving huge attention in the last few years, due to its biomedical applications versatility such as diagnoses, magnetic resonance imaging, cancer treatment, controlled drug delivery, among others. Likewise, silver nanoparticles (Ag) show powerful antibacterial action and are employed in the food, textile, pharmaceutical and agricultural industries. In this context, this project aims the synthesis and characterization of Fe3O4/Ag, involving chemical and biogenic synthesis, being: (i) superparamagnetic and (ii) antibacterial. The application of an external magnetic field can also be used to remove these nanoparticles from the medium of interest, this action implies in the nanoparticles reuse in biomedical applications, as well on the proper removal from the environment. To improve nanoparticles antibacterial action, besides improving its aqueous dispersion and biocompatibility, the surface of the Fe3O4/Ag will be coated with chitosan, a natural biocompatible, biodegradable and antimicrobial polymer. Furthermore, the coating with chitosan nanoparticles enable the incorporation of nitric oxide donors, well known for its antibacterial properties. Therefore, this project includes the preparation of hybrid, magnetic and antimicrobial nanoparticles, using chemical and biogenic methods with great potential to biomedical applications. (AU)

Scientific publications

(16)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOURENCO, ISABELLA M.; PIERETTI, JOANA C.; NASCIMENTO, MONICA HELENA M.; LOMBELLO, CHRISTIANE B.; SEABRA, AMEDEA B.. Eco-friendly synthesis of iron nanoparticles by green tea extract and cytotoxicity effects on tumoral and non-tumoral cell lines. ENERGY ECOLOGY AND ENVIRONMENT, v. 4, n. 6, p. 10-pg., 2019-12-01. (18/08194-2, 18/02832-7)

ROLIM, WALLACE R.; PIERETTI, JOANA C.; RENO, DEBORA L. S.; LIMA, BRUNA A.; NASCIMENTO, MONICA H. M.; AMBROSIO, FELIPE N.; LOMBELLO, CHRISTIANE B.; BROCCHI, MARCELO; DE SOUZA, ANA CAROLINA S.; SEABRA, AMEDEA B.. Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 6, p. 6589-6604, FEB 13 2019. (16/10347-6, 18/02832-7)

TORTELLA, G. R.; PIERETTI, J. C.; RUBILAR, O.; FERNANDEZ-BALDO, M.; BENAVIDES-MENDOZA, A.; DIEZ, M. C.; SEABRA, A. B.. Silver, copper and copper oxide nanoparticles in the fight against human viruses: progress and perspectives. CRITICAL REVIEWS IN BIOTECHNOLOGY, JUL 2021. (18/08194-2, 18/02832-7)

PELEGRINO, MILENA T.; PIERETTI, JOANA C.; NAKAZATO, GERSON; GONCALVES, MARCELLY CHUE; MOREIRA, JOSE CARLOS; SEABRA, AMEDEA B.. Chitosan chemically modified to deliver nitric oxide with high antibacterial activity. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 106, p. 24-34, JAN 1 2021. (18/08194-2, 17/05029-8, 18/02832-7)

TORTELLA, GONZALO R.; RUBILAR, OLGA; DIEZ, MARIA CRISTINA; PADRAO, JORGE; ZILLE, ANDREA; PIERETTI, JOANA C.; SEABRA, AMEDEA B.. Advanced Material Against Human (Including Covid-19) and Plant Viruses: Nanoparticles As a Feasible Strategy. GLOBAL CHALLENGES, v. 5, n. 3, DEC 2020. (18/02832-7, 18/08194-2)

PIERETTI, JOANA CLAUDIO; CRUZ JUNHO, CAROLINA VICTORIA; CARNEIRO-RAMOS, MARCELA SORELLI; SEABRA, AMEDEA BAROZZI. H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury. PHARMACOLOGICAL RESEARCH, v. 161, NOV 2020. (18/02832-7, 18/03089-6, 18/08194-2, 15/19107-5)

PIERETTI, JOANA C.; ROLIM, WALLACE R.; FERREIRA, FABIO F.; LOMBELLO, CHRISTIANE B.; NASCIMENTO, MONICA H. M.; SEABRA, AMEDEA B.. Synthesis, Characterization, and Cytotoxicity of Fe3O4@Ag Hybrid Nanoparticles: Promising Applications in Cancer Treatment. JOURNAL OF CLUSTER SCIENCE, v. 31, n. 2, p. 535-547, MAR 2020. (18/08194-2, 18/02832-7)

GALLARDO-BENAVENTE, CARLA; CARRION, ORNELLA; TODD, JONATHAN D.; PIERETTI, JOANA C.; SEABRA, AMEDEA B.; DURAN, NELSON; RUBILAR, OLGA; PEREZ-DONOSO, JOSE M.; QUIROZ, ANDRES. Biosynthesis of CdS Quantum Dots Mediated by Volatile Sulfur Compounds Released by Antarctic Pseudomonas fragi. FRONTIERS IN MICROBIOLOGY, v. 10, AUG 13 2019. (18/08194-2, 18/02832-7)

ROLIM, WALLACE R.; LAMILLA, CLAUDIO; PIERETTI, JOANA C.; DIAZ, MARCELA; TORTELLA, GONZALO R.; CRISTINA DIEZ, M.; BARRIENTOS, LETICIA; SEABRA, AMEDEA B.; RUBILAR, OLGA. Comparison of antibacterial and antibiofilm activities of biologically synthesized silver nanoparticles against several bacterial strains of medical interest. ENERGY ECOLOGY AND ENVIRONMENT, v. 4, n. 4, p. 17-pg., 2019-08-01. (18/08194-2, 18/02832-7)

PIERETTI, JOANA C.; PELEGRINO, MILENA T.; NASCIMENTO, MONICA H. M.; TORTELLA, GONZALO R.; RUBILAR, OLGA; SEABRA, AMEDEA B.. Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?. Biochemical Pharmacology, v. 176, n. SI, JUN 2020. (18/08194-2, 17/05029-8, 18/02832-7)

NASCIMENTO, MONICA H. M.; PELEGRINO, MILENA T.; PIERETTI, JOANA C.; SEABRAL, AMEDEA B.. How can nitric oxide help osteogenesis?. AIMS MOLECULAR SCIENCE, v. 7, n. 1, p. 29-48, 2020. (18/08194-2, 17/05029-8, 18/02832-7)

PIERETTI, JOANA C.; BEURTON, JORDAN; MUNEVAR, JULIAN; NAGAMINE, LUIZ C. C. M.; LE FAOU, ALAIN; SEABRA, AMEDEA B.; CLAROT, IGOR; BOUDIER, ARIANE. The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 19, OCT 2021. (18/02832-7, 19/07766-5)

PIERETTI, JOANA CLAUDIO; GONCALVES, MARCELLY CHUE; NAKAZATO, GERSON; SANTOS DE SOUZA, ANA CAROLINA; BOUDIER, ARIANE; SEABRA, AMEDEA BAROZZI. Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 32, n. 3, MAR 2021. (19/07766-5, 18/08194-2, 18/02832-7)

PIERETTI, JOANA C.; PELEGRINO, MILENA T.; NASCIMENTO, MONICA H. M.; TORTELLA, GONZALO R.; RUBILAR, OLGA; SEABRA, AMEDEA B.. Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?. Biochemical Pharmacology, v. 176, p. 13-pg., 2020-06-01. (18/08194-2, 18/02832-7, 17/05029-8)

LOURENCO, I. M.; PELEGRINO, M. T.; PIERETTI, J. C.; ANDRADE, G. P.; CERCHIARO, G.; SEABRA, A. B.; IOP. Synthesis, characterization and cytotoxicity of chitosan-coated Fe3O4 nanoparticles functionalized with ascorbic acid for biomedical applications. WAKE CONFERENCE 2021, v. 1323, p. 10-pg., 2019-01-01. (18/02832-7, 16/10347-6, 18/13761-3, 16/09652-9, 17/05029-8)

CAIO-SILVA, WELLINGTON; DA SILVA DIAS, DANIELLE; JUNHO, CAROLINA VICTORIA CRUZ; PANICO, KARINE; NERES-SANTOS, RAQUEL SILVA; PELEGRINO, MILENA TREVISAN; PIERETTI, JOANA CLAUDIO; SEABRA, AMEDEA BAROZZI; DE ANGELIS, KATIA; CARNEIRO-RAMOS, MARCELA SORELLI. Characterization of the Oxidative Stress in Renal Ischemia/Reperfusion-Induced Cardiorenal Syndrome Type 3. BIOMED RESEARCH INTERNATIONAL, v. 2020, OCT 9 2020. (18/02832-7, 18/08194-2, 08/10175-4, 17/05029-8, 19/11077-0)