Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women

Author(s):Show less -

Neves, Jr., Manoel ^[1] ; Gualano, Bruno ^{[2, 1]} ; Roschel, Hamilton ^{[2, 1]} ; Lima, Fernanda Rodrigues ^[1] ; de Sa-Pinto, Ana Lucia ^[1] ; Seguro, Antonio Carlos ^[3] ; Shimizu, Maria Heloisa ^[3] ; Sapienza, Marcelo Tatit ^[4] ; Fuller, Ricardo ^[1] ; Lancha, Jr., Antonio Herbert ^[2] ; Bonfa, Eloisa ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Div Rheumatol, BR-01246903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, BR-01246903 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Div Nephrol, BR-01246903 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Div Nucl Med, BR-01246903 Sao Paulo - Brazil

• Document type: Journal article
• Source: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM; v. 36, n. 3, p. 419-422, JUN 2011.
• Web of Science Citations: 13

Abstract

We aimed to investigate whether creatine supplementation affects the measured glomerular filtration rate in postmenopausal women (age, 58 +/- 3 years). Subjects were randomly assigned to receive either creatine (20 g(.)day(-1) for 1 week and 5 g(.)day(-1) thereafter) or a placebo. Kidney function was assessed at baseline and after 12 weeks. {[}(51)Cr] EDTA clearance remained unchanged (CR-PRE: 86.16 +/- 14.36 mL(.)min(-1) per 1.73 m(2), POST: 87.25 +/- 17.60 mL(.)min(-1) per 1.73 m(2); PL-PRE: 85.15 +/- 8.54 mL(.)min(-1) per 1.73 m(2), POST: 87.18 +/- 9.64 mL(.)min(-1) per 1.73 m(2); p = 0.81). Thus, we concluded that creatine supplementation does not affect glomerular filtration rate in postmenopausal women. (AU)