A Concise Account on Organocatalyzed Asymmetric Synthesis of Epoxide and Aziridine Derivatives from α,β-Unsaturated Carbonyl Compounds

Author(s)

Martinez, Alice K. de A. ; Mourao, Penina S. ; Correa, Arlene G.

• Document type: Journal article
• Source: Synlett; v. N/A, p. 9-pg., 2025-03-12.

Abstract

Epoxides and aziridines are important pharmacologically active compounds that are found in many drugs. These three-membered rings are also employed in the synthesis of a wide range of other heterocycles. In this account, we highlight the contributions of our research group to the organocatalyzed asymmetric synthesis of epoxides and aziridines from a,(3-unsaturated carbonyl compounds, followed by multicomponent reactions that afford novel peptidomimetics. Additionally, these scaffolds have been employed in the synthesis of lac- tones, lactams, and hydantoins, showcasing their versatility in drug development and synthetic chemistry. (AU)

• FAPESP's process: 24/05518-2 - Synthesis of five-membered N-heterocycles employing green methods
• Grantee: Alice Karoline de Almeida Martinez
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 21/12394-0 - Sustainable synthetic methods employing catalysis, benign solvents, safer reagents, and bio-renewable feedstock
• Grantee: Arlene Gonçalves Corrêa
• Support Opportunities: Research Projects - Thematic Grants