| Full text | |
| Author(s): Show less - |
Bruxel, Estela M.
;
Rovaris, Diego L.
;
Belangero, Sintia I.
;
Chavarria-Soley, Gabriela
;
Cuellar-Barboza, Alfredo B.
;
Martinez-Magana, Jose J.
;
Nagamatsu, Sheila T.
;
Nievergelt, Caroline M.
;
Nunez-Rios, Diana L.
;
Ota, Vanessa K.
;
Peterson, Roseann E.
;
Sloofman, Laura G.
;
Adams, Amy M.
;
Albino, Elinette
;
Alvarado, Angel T.
;
Andrade-Brito, Diego
;
Arguello-Pascualli, Paola Y.
;
Bandeira, Cibele E.
;
Bau, Claiton H. D.
;
Bulik, Cynthia M.
;
Buxbaum, Joseph D.
;
Cappi, Carolina
;
Corral-Frias, Nadia S.
;
Corrales, Alejo
;
Corsi-Zuelli, Fabiana
;
Crowley, James J.
;
Cupertino, Renata B.
;
da Silva, Bruna S.
;
De Almeida, Suzannah S.
;
de la Hoz, Juan F.
;
Forero, Diego A.
;
Fries, Gabriel R.
;
Gelernter, Joel
;
Gonzalez-Giraldo, Yeimy
;
Grevet, Eugenio H.
;
Grice, Dorothy E.
;
Hernandez-Garayua, Adriana
;
Hettema, John M.
;
Ibanez, Agustin
;
Ionita-Laza, Iuliana
;
Lattig, Maria Claudia
;
Lima, Yago C.
;
Lin, Yi-Sian
;
Lopez-Leon, Sandra
;
Loureiro, Camila M.
;
Martinez-Cerdeno, Veronica
;
Martinez-Levy, Gabriela A.
;
Melin, Kyle
;
Moreno-De-Luca, Daniel
;
Carvalho, Carolina Muniz
;
Olivares, Ana Maria
;
Oliveira, Victor F.
;
Ormond, Rafaella
;
Palmer, Abraham A.
;
Panzenhagen, Alana C.
;
Passos-Bueno, Maria Rita
;
Peng, Qian
;
Perez-Palma, Eduardo
;
Prieto, Miguel L.
;
Roussos, Panos
;
Sanchez-Roige, Sandra
;
Santamaria-Garcia, Hernando
;
Shansis, Flavio M.
;
Sharp, Rachel R.
;
Storch, Eric A.
;
Tavares, Maria Eduarda A.
;
Tietz, Grace E.
;
Torres-Hernandez, Bianca A.
;
Tovo-Rodrigues, Luciana
;
Trelles, Pilar
;
Trujillo-ChiVacuan, Eva M.
;
Velasquez, Maria M.
;
Vera-Urbina, Fernando
;
Voloudakis, Georgios
;
Wegman-Ostrosky, Talia
;
Zhen-Duan, Jenny
;
Zhou, Hang
;
Santoro, Marcos L.
;
Nicolini, Humberto
;
Atkinson, Elizabeth G.
;
Giusti-Rodriguez, Paola
;
Montalvo-Ortiz, Janitza L.
Total Authors: 82
|
| Document type: | Journal article |
| Source: | Nature Genetics; v. N/A, p. 15-pg., 2025-04-02. |
| Abstract | |
Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics. (AU) | |
| FAPESP's process: | 19/13229-2 - Inflammatory profile in the general population: transdiagnostic dimensions in the context of the psychosis continuum |
| Grantee: | Fabiana Maria das Graças Corsi Zuelli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 21/15030-9 - Development of a protocol for genome-wide association study to be applied to the investigation of mesial temporal lobe epilepsy in admixed Brazilians |
| Grantee: | Estela Maria Bruxel |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 20/15752-1 - Cannabis use, childhood trauma and endocannabinoids and glutamatergic variants: risk for psychosis |
| Grantee: | Camila Marcelino Loureiro |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/05652-0 - The physiological genomics of mental health from the perspective of the Brazilian exposome |
| Grantee: | Diego Luiz Rovaris |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 23/05560-6 - Genetic and epigenetic approaches as predictive models in mental disorders |
| Grantee: | Marcos Leite Santoro |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 23/12252-6 - Epigenetic aspects involved in ADHD and related phenotypes |
| Grantee: | Cibele Edom Bandeira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |