Advanced search
Start date
Betweenand

Latitudinal landscape genomics and ecology of Anopheles darlingi

Abstract

The primary Amazonian malaria vector Anopheles darlingi has the ability to adapt quickly to micro- geographic changes resulting from novel environmental conditions such as those encountered in agricultural settlements. Therefore, it is a substantial health threat in Latin America. This proposal examines three understudied aspects of An. darlingi to identify the main mechanism responsible for its success in transmission: broad plasticity or genetic specialization. First, we will test the Frontier Malaria Hypothesis (FMH), that settlement age predicts malaria incidence, by explicitly separating the effects of settlement age and forest cover. We will use a state-of-the art ecologically based experimental design that compares environmental variables in three levels of forest cover and two habitat types in both new and old settlements in two regions of Amazonian Brazil. Entomological metrics, most notably the entomological inoculation rate (EIR), will be compared among 12 settlements. We anticipate that a modified FMH, that accounts for both age and forest cover, will provide stronger predictive power for the invasiveness of An. darlingi and other vectors in a wide range of fragmented landscape types. Secondly, we will compare population genomics of An. darlingi exposed to (i) different levels of Plasmodium in the endemic Amazonian region versus southern Brazil where malaria is rare, and (ii) environmental variables in multiple Amazonian settlements. Development of SNPs across the An. darlingi genome will allow us to determine whether populations of An. darlingi differ in their genetic capacity to resist Plasmodium and to discover genomic signatures of selection among populations and regions. Thirdly, we will conduct life-history experiments that focus on the reaction norms to temperature of traits that are directly linked to vectorial capacity. We will test for regional genetic variation for traits and their plasticities, and evaluate whether there has been selection for these differences. By providing original data on the genotypic and phenotypic characteristics integral to the rapid response of An. darlingi to landscape fragmentation, our work will have a significant impact on frontier malaria in the Amazon and in other similar settings. The proposed work is conceptually innovative because it links landscape fragmentation, genetics and life history traits with the precise localities that are likely to become foci of increased transmission. It is technically innovative because of the use of a next-gen RADseq method to evaluate populations of An. darlingi from localities with varying exposure to Plasmodium. Our long-term goal is to predict where and when An. darlingi populations will expand, resulting in new foci of malaria risk. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (42)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALLUM, MARIA ANICE M.; CONN, JAN E.; BERGO, EDUARDO S.; LAPORTA, GABRIEL Z.; CHAVES, LEONARDO S. M.; BICKERSMITH, SARA A.; DE OLIVEIRA, TATIANE M. P.; FIGUEIRA, ELDER AUGUSTO G.; MORESCO, GILBERTO; OLIVER, LEUDA; et al. Vector competence, vectorial capacity of Nyssorhynchus darlingi and the basic reproduction number of Plasmodium vivax in agricultural settlements in the Amazonian Region of Brazil. Malaria Journal, v. 18, . (14/26229-7, 14/09774-1)
MOREIRA CHAVES, LEONARDO SUVEGES; CONN, JAN E.; MENDOZA LOPEZ, ROSSANA VERONICA; MUREB SALLUM, MARIA ANICE. Abundance of impacted forest patches less than 5 km(2) is a key driver of the incidence of malaria in Amazonian Brazil. SCIENTIFIC REPORTS, v. 8, . (14/26229-7, 14/26855-5)
OLIVEIRA, T. M. P.; FOSTER, P. G.; BERGO, E. S.; NAGAKI, S. S.; SANABANI, S. S.; MARINOTTI, O.; MARINOTTI, P. N.; SALLUM, M. A. M.. Mitochondrial Genomes of Anopheles (Kerteszia) (Diptera: Culicidae) From the Atlantic Forest, Brazil. Journal of Medical Entomology, v. 53, n. 4, p. 790-797, . (14/26229-7)
NARANJO-DIAZ, NELSON; SALLUM, MARIA ANICE M.; CORREA, MARGARITA M.. Population dynamics of Anopheles nuneztovari in Colombia. INFECTION GENETICS AND EVOLUTION, v. 45, p. 56-65, . (14/26229-7)
AMAKU, M.; AZEVEDO, F.; BURATTINI, M. N.; COELHO, G. E.; COUTINHO, F. A. B.; GREENHALGH, D.; LOPEZ, L. F.; MOTITSUKI, R. S.; WILDER-SMITH, A.; MASSAD, E.. Magnitude and frequency variations of vector-borne infection outbreaks using the Ross-Macdonald model: explaining and predicting outbreaks of dengue fever. EPIDEMIOLOGY AND INFECTION, v. 144, n. 16, p. 3435-3450, . (14/26229-7, 14/26327-9)
MARTEIS, LETICIA SILVA; NATAL, DELSIO; MUREB SALLUM, MARIA ANICE; MEDEIROS-SOUSA, ANTONIO RALPH; PORANGABA OLIVEIRA, TATIANE MARQUES; LA CORTE, ROSELI. Mosquitoes of the Caatinga: 1. Adults stage survey and the emerge of seven news species endemic of a dry tropical forest in Brazil. Acta Tropica, v. 166, p. 193-201, . (14/26229-7)
DEMARI-SILVA, BRUNA; MULTINI, LAURA CRISTINA; SUESDEK, LINCOLN; OLIVEIRA, TATIANE M. P.; MUREB SALLUM, MARIA ANICE; MARRELLI, MAURO TOLEDO. Wing Morphometry and Genetic Variability Between Culex coronator and Culex usquatus (Diptera: Culicidae), Two Sibling Species of the Coronator Group. Journal of Medical Entomology, v. 54, n. 4, p. 901-908, . (14/26229-7, 10/02658-5)
FOSTER, PETER G.; PORANGABA DE OLIVEIRA, TATIANE MARQUES; BERGO, EDUARDO S.; CONN, JAN E.; SANT'ANA, DENISE CRISTINA; NAGAKI, SANDRA SAYURI; NIHEI, SILVIO; LAMAS, CARLOS EINICKER; GONZALEZ, CHRISTIAN; MOREIRA, CAIO CESAR; et al. Phylogeny of Anophelinae using mitochondrial protein coding genes. ROYAL SOCIETY OPEN SCIENCE, v. 4, n. 11, . (14/26229-7, 11/20397-7)
PRUSSING, CATHARINE; EMERSON, KEVIN J.; BICKERSMITH, SARA A.; MUREB SALLUM, MARIA ANICE; CONN, JAN E.. Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil. PLoS One, v. 14, n. 11, . (14/26229-7)
TATIANE M. P. OLIVEIRA; SABRI S. SANABANI; MARIA ANICE M. SALLUM. Asaia (Rhodospirillales: Acetobacteraceae) and Serratia (Enterobacterales: Yersiniaceae) associated with Nyssorhynchus braziliensis and Nyssorhynchus darlingi (Diptera: Culicidae). Revista Brasileira de Entomologia, v. 64, n. 2, . (14/26229-7)
MASSAD, EDUARDO; LAPORTA, GABRIEL ZORELLO; CONN, JAN EVELYN; CHAVES, LEONARDO SUVEGES; BERGO, EDUARDO STERLINO; GUIMARAES FIGUEIRA, ELDER AUGUSTO; BEZERRA COUTINHO, FRANCISCO ANTONIO; LOPEZ, LUIS FERNANDEZ; STRUCHINER, CLAUDIO; MUREB SALLUM, MARIA ANICE. The risk of malaria infection for travelers visiting the Brazilian Amazonian region: A mathematical modeling approach. TRAVEL MEDICINE AND INFECTIOUS DISEASE, v. 37, . (14/26229-7, 14/09774-1)
DE OLIVEIRA PADILHA, MEYRECLER AGLAIR; MELO, JANILLE DE OLIVEIRA; ROMANO, GUILHERME; MALVEIRA DE LIMA, MARCOS VINICIUS; ALONSO, WLADIMIR J.; MUREB SALLUM, MARIA ANICE; LAPORTA, GABRIEL ZORELLO. Comparison of malaria incidence rates and socioeconomic-environmental factors between the states of Acre and Rondonia: a spatio-temporal modelling study. Malaria Journal, v. 18, n. 1, . (14/26229-7, 15/09669-6, 14/09774-1)
NAGAKI, SANDRA SAYURI; CHAVES, LEONARDO S. M.; LOPEZ, ROSSANA VEONICA MENDOZA; BERGO, EDUARDO S.; LAPORTA, GABRIEL Z.; CONN, JAN E.; SALLUM, MARIA ANICE MUREB. Host feeding patterns of Nyssorhynchus darlingi (Diptera: Culicidae) in the Brazilian Amazon. Acta Tropica, v. 213, . (16/08562-6, 14/26229-7, 14/09774-1)
OLIVEIRA, TATIANE MARQUES PORANGABA; SANABANI, SABRI SAEED; SALLUM, MARIA ANICE MUREB. Bacterial diversity associated with the abdomens of naturallyPlasmodium-infected and non-infectedNyssorhynchus darlingi. BMC Microbiology, v. 20, n. 1, . (14/26229-7)
CHAVES, LEONARDO SUVEGES MOREIRA; FRY, JACOB; MALIK, ARUNIMA; GESCHKE, ARNE; SALLUM, MARIA ANICE MUREB; LENZEN, MANFRED. Global consumption and international trade in deforestation-associated commodities could influence malaria risk. NATURE COMMUNICATIONS, v. 11, n. 1, . (14/26855-5, 14/26229-7)
SILVA-DO-NASCIMENTO, TERESA FERNANDES; SANCHEZ-RIBAS, JORDI; OLIVEIRA, TATIANE M. P.; BOURKE, BRIAN PATRICK; OLIVEIRA-FERREIRA, JOSELI; ROSA-FREITAS, MARIA GORETI; LOURENCO-DE-OLIVEIRA, RICARDO; MARINHO-E-SILVA, MARIANA; NEVES, MAYCON SEBASTIAO ALBERTO SANTOS; CONN, JAN E.; et al. olecular Analysis Reveals a High Diversity of Anopheline Mosquitoes in Yanomami Lands and the Pantanal Region of Brazi. GENES, v. 12, n. 12, . (14/26229-7)
OLIVEIRA, TATIANE M. P.; LAPORTA, GABRIEL Z.; BERGO, EDUARDO S.; CHAVES, LEONARDO SUVEGES MOREIRA; ANTUNES, JOSE LEOPOLDO F.; BICKERSMITH, SARA A.; CONN, JAN E.; MASSAD, EDUARDO; SALLUM, MARIA ANICE MUREB. Vector role and human biting activity of Anophelinae mosquitoes in different landscapes in the Brazilian Amazon. PARASITES & VECTORS, v. 14, n. 1, . (14/26229-7, 14/09774-1)
ALONSO, DIEGO PERES; NIZ ALVAREZ, MARCUS VINICIUS; MARTINS RIBOLLA, PAULO EDUARDO; CONN, JAN E.; PORANGABA DE OLIVEIRA, TATIANE MARQUES; MUREB SALLUM, MARIA ANICE. Susceptibility of Field-Collected Nyssorhynchus darlingi to Plasmodium spp. in Western Amazonian Brazil. GENES, v. 12, n. 11, . (14/26229-7)
CHAVES, LEONARDO SUVEGES MOREIRA; BERGO, EDUARDO STERLINO; CONN, JAN E.; LAPORTA, GABRIEL ZORELLO; PRIST, PAULA RIBEIRO; SALLUM, MARIA ANICE MUREB. Anthropogenic landscape decreases mosquito biodiversity and drives malaria vector proliferation in the Amazon rainforest. PLoS One, v. 16, n. 1, . (14/26229-7, 14/26855-5, 14/09774-1)
DEMARI-SILVA, BRUNA; FOSTER, PETER G.; DE OLIVEIRA, TATIANE M. P.; BERGO, EDUARDO S.; SANABANI, SABRI S.; PESSOA, RODRIGO; SALLUM, MARIA ANICE M.. Mitochondrial genomes and comparative analyses of Culex camposi, Culex coronator, Culex usquatus and Culex usquatissimus (Diptera:Culicidae), members of the coronator group. BMC Genomics, v. 16, . (14/26229-7)
TORRES-GUTIERREZ, CAROLINA; MUREB SALLUM, MARIA ANICE. Catalog of the subgenus Melanoconion of Culex (Diptera: Culicidae) for South America. Zootaxa, v. 4028, n. 1, p. 1-50, . (14/26229-7, 12/18089-5)
LAPORTA, GABRIEL Z.; ILACQUA, ROBERTO C.; BERGO, EDUARDO S.; CHAVES, LEONARDO S. M.; RODOVALHO, SHEILA R.; MORESCO, GILBERTO G.; FIGUEIRA, ELDER A. G.; MASSAD, EDUARDO; DE OLIVEIRA, TATIANE M. P.; BICKERSMITH, SARA A.; et al. Malaria transmission in landscapes with varying deforestation levels and timelines in the Amazon: a longitudinal spatiotemporal study. SCIENTIFIC REPORTS, v. 11, n. 1, . (14/09774-1, 14/26229-7)
MUREB SALLUM, MARIA ANICE; OBANDO, RANULFO GONZALEZ; CARREJO, NANCY; WILKERSON, RICHARD C.. Identification keys to the Anopheles mosquitoes of South America (Diptera: Culicidae). II. Fourth-instar larvae. PARASITES & VECTORS, v. 13, n. 1, . (14/26229-7)
MUREB SALLUM, MARIA ANICE; OBANDO, RANULFO GONZALEZ; CARREJO, NANCY; WILKERSON, RICHARD C.. Identification keys to the Anopheles mosquitoes of South America (Diptera: Culicidae). IV. Adult females. PARASITES & VECTORS, v. 13, n. 1, . (14/26229-7)
HUTCHINGS, ROSA SA GOMES; HUTCHINGS, ROGER WILLIAM; MENEZES, ISIS SA; SALLUM, MARIA ANICE MUREB. Mosquitoes (Diptera: Culicidae) From the Southwestern Brazilian Amazon: Liberdade and Gregorio Rivers. Journal of Medical Entomology, v. 57, n. 6, p. 1793-1811, . (14/26229-7)
DE SA, IVY LUIZI RODRIGUES; HUTCHINGS, ROSA SA GOMES; HUTCHINGS, ROGER WILLIAM; SALLUM, MARIA ANICE MUREB. Revision of the Atratus Group of Culex (Melanoconion) (Diptera: Culicidae). PARASITES & VECTORS, v. 13, n. 1, . (14/26229-7, 16/25604-4, 15/05109-6)
KIRCHGATTER, KARIN; DE OLIVEIRA GUIMARAES, LILIAN; YANEZ TRUJILLANO, HENRRY HUGO; RAFAEL ARIAS, FERNANDO; GERMAN CACERES, ABRAHAM; RIBEIRO DE CASTRO DUARTE, ANA MARIA; MALAFRONTE, ROSELY DOS SANTOS; TUBAKI, ROSA MARIA; MUREB SALLUM, MARIA ANICE. Phylogeny of Anopheles (Kerteszia) (Diptera: Culicidae) Using Mitochondrial Genes. INSECTS, v. 11, n. 5, . (14/26229-7, 18/16232-1)
DEMARI-SILVA, B.; LAPORTA, G. Z.; OLIVEIRA, T. M. P.; SALLUM, M. A. M.. Plasmodium infection in Kerteszia cruzii (Diptera: Culicidae) in the Atlantic tropical rain forest, southeastern Brazil. INFECTION GENETICS AND EVOLUTION, v. 78, . (14/26229-7, 16/08551-4, 14/09774-1)
LAPORTA, GABRIEL ZORELLO; LINTON, YVONNE-MARIE; WILKERSON, RICHARD C.; BERGO, EDUARDO STERLINO; NAGAKI, SANDRA SAYURI; SANT'ANA, DENISE CRISTINA; MUREB SALLUM, MARIA ANICE. Malaria vectors in South America: current and future scenarios. PARASITES & VECTORS, v. 8, . (14/26229-7, 14/09774-1, 15/09669-6)
TORRES-GUTIERREZ, CAROLINA; BERGO, EDUARDO STERLINO; EMERSON, KEVIN J.; DE OLIVEIRA, TATIANE M. P.; GRENI, SUSAN; MUREB SALLUM, MARIA ANICE. Mitochondrial COI gene as a tool in the taxonomy of mosquitoes Culex subgenus Melanoconion. Acta Tropica, v. 164, p. 137-149, . (14/26229-7, 12/18089-5)
RUFALCO-MOUTINHO, PAULO; SCHWEIGMANN, NICOLAS; BERGAMASCHI, DENISE PIMENTEL; MUREB SALLUM, MARIA ANICE. Larval habitats of Anopheles species in a rural settlement on the malaria frontier of southwest Amazon, Brazil. Acta Tropica, v. 164, p. 243-258, . (14/26229-7)
DE AZEVEDO, THIAGO S.; BOURKE, BRIAN PATRICK; PIOVEZAN, RAFAEL; SALLUM, MARIA ANICE M.. The influence of urban heat islands and socioeconomic factors on the spatial distribution of Aedes aegypti larval habitats. GEOSPATIAL HEALTH, v. 13, n. 1, p. 179-187, . (14/26229-7)
DENISE CRISTINA SANT'ANA; MARIA ANICE MUREB SALLUM. Anopheles (Nyssorhynchus) striatus, a new species of the Strodei Subgroup (Diptera, Culicidae). Revista Brasileira de Entomologia, v. 61, n. 2, p. 136-145, . (14/26229-7)
BOURKE, BRIAN P.; CONN, JAN E.; DE OLIVEIRA, TATIANE M. P.; CHAVES, LEONARDO S. M.; BERGO, EDUARDO S.; LAPORTA, GABRIEL Z.; SALLUM, MARIA A. M.. Exploring malaria vector diversity on the Amazon Frontier. Malaria Journal, v. 17, . (14/26229-7, 14/09774-1)
MARTEIS, L. S.; SALLUM, M. A. M.; NATAL, D.; OLIVEIRA, T. M. P.; GAMA, R. A.; DOLABELLA, S. S.; SANTOS, R. L. C.. First Record of Anopheles oryzalimnetes, Anopheles argyritarsis, and Anopheles sawyeri (Diptera: Culicidae) in the Caatinga Biome, Semiarid Scrubland of Sergipe State, Brazil. Journal of Medical Entomology, v. 52, n. 5, p. 858-865, . (14/26229-7)
CHU, VIRGINIA M.; MUREB SALLUM, MARIA ANICE; MOORE, TIMOTHY E.; EMERSON, KEVIN J.; SCHLICHTING, CARL D.; CONN, JAN E.. Evidence for family-level variation of phenotypic traits in response to temperature of Brazilian Nyssorhynchus darlingi. PARASITES & VECTORS, v. 13, n. 1, . (14/26229-7)
HUTCHINGS, R. S. G.; HUTCHINGS, R. W.; MENEZES, I. S.; MOTTA, M. DE A.; SALLUM, M. A. M.. Mosquitoes (Diptera: Culicidae) From the Northwestern Brazilian Amazon: Padauari River. Journal of Medical Entomology, v. 53, n. 6, p. 1330-1347, . (14/26229-7)
TORRES-GUTIERREZ, CAROLINA; DE OLIVEIRA, TATIANE M. P.; EMERSON, KEVIN J.; BERGO, EDUARDO STERLINO; MUREB SALLUM, MARIA ANICE. Molecular phylogeny of Culex subgenus Melanoconion (Diptera: Culicidae) based on nuclear and mitochondrial protein-coding genes. ROYAL SOCIETY OPEN SCIENCE, v. 5, n. 5, . (14/26229-7, 12/18089-5)
DEMARI-SILVA, BRUNA; LAPORTA, GABRIEL ZORELLO; DE OLIVEIRA, TATIANE MARQUES PORANGABA; SALLUM, MARIA ANICE MUREB. Evidence of Elevational Speciation in Kerteszia cruzii (Diptera: Culicidae) in the Ribeira Valley, Sao Paulo, Brazil. FRONTIERS IN ECOLOGY AND EVOLUTION, v. 9, . (14/09774-1, 14/26229-7, 16/08551-4)
PIOVEZAN, RAFAEL; VISOCKAS, ALEXANDRE; DE AZEVEDO, THIAGO SALOMAO; VON ZUBEN, CLAUDIO JOSE; MUREB SALLUM, MARIA ANICE. Spatial-temporal distribution of Aedes (Stegomyia) aegypti and locations of recycling units in southeastern Brazil. PARASITES & VECTORS, v. 12, n. 1, . (14/26229-7)
SALLUM, MARIA ANICE MUREB; OBANDO, RANULFO GONZALEZ; CARREJO, NANCY; WILKERSON, RICHARD C.. Identification key to the Anopheles mosquitoes of South America (Diptera: Culicidae). III. Male genitalia. PARASITES & VECTORS, v. 13, n. 1, . (14/26229-7)
GRENI, SUSAN ELAINE; DEMARI-SILVA, BRUNA; PORANGABA DE OLIVEIRA, TATIANE MARQUES; SUESDEK, LINCOLN; LAPORTA, GABRIEL ZORELLO; MUREB SALLUM, MARIA ANICE. A Multi-Gene Analysis and Potential Spatial Distribution of Species of the Strodei Subgroup of the Genus Nyssorhynchus (Diptera: Culicidae). Journal of Medical Entomology, v. 55, n. 6, p. 1486-1495, . (14/26229-7, 14/09774-1)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.