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Latitudinal landscape genomics and ecology of Anopheles darlingi

Abstract

The primary Amazonian malaria vector Anopheles darlingi has the ability to adapt quickly to micro- geographic changes resulting from novel environmental conditions such as those encountered in agricultural settlements. Therefore, it is a substantial health threat in Latin America. This proposal examines three understudied aspects of An. darlingi to identify the main mechanism responsible for its success in transmission: broad plasticity or genetic specialization. First, we will test the Frontier Malaria Hypothesis (FMH), that settlement age predicts malaria incidence, by explicitly separating the effects of settlement age and forest cover. We will use a state-of-the art ecologically based experimental design that compares environmental variables in three levels of forest cover and two habitat types in both new and old settlements in two regions of Amazonian Brazil. Entomological metrics, most notably the entomological inoculation rate (EIR), will be compared among 12 settlements. We anticipate that a modified FMH, that accounts for both age and forest cover, will provide stronger predictive power for the invasiveness of An. darlingi and other vectors in a wide range of fragmented landscape types. Secondly, we will compare population genomics of An. darlingi exposed to (i) different levels of Plasmodium in the endemic Amazonian region versus southern Brazil where malaria is rare, and (ii) environmental variables in multiple Amazonian settlements. Development of SNPs across the An. darlingi genome will allow us to determine whether populations of An. darlingi differ in their genetic capacity to resist Plasmodium and to discover genomic signatures of selection among populations and regions. Thirdly, we will conduct life-history experiments that focus on the reaction norms to temperature of traits that are directly linked to vectorial capacity. We will test for regional genetic variation for traits and their plasticities, and evaluate whether there has been selection for these differences. By providing original data on the genotypic and phenotypic characteristics integral to the rapid response of An. darlingi to landscape fragmentation, our work will have a significant impact on frontier malaria in the Amazon and in other similar settings. The proposed work is conceptually innovative because it links landscape fragmentation, genetics and life history traits with the precise localities that are likely to become foci of increased transmission. It is technically innovative because of the use of a next-gen RADseq method to evaluate populations of An. darlingi from localities with varying exposure to Plasmodium. Our long-term goal is to predict where and when An. darlingi populations will expand, resulting in new foci of malaria risk. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Relacionan el riesgo malárico con la demanda de productos básicos agrícolas en áreas de deforestación 
Study links malaria risk in deforestation hotspots to demand for agricultural commodities 
Estudo relaciona risco de malária em áreas de desmatamento à demanda por <i>commodities</i> agrícolas 
Articles published in other media outlets (27 total):
More itemsLess items
Eurasia Review (Espanha): Study Links Malaria Risk In Deforestation Hotspots To Demand For Agricultural Commodities (08/Jun/2020)
FBI Reform (EUA): Study Links Malaria Risk In Deforestation Hotspots To Demand For Agricultural Commodities (08/Jun/2020)
Mundo Agropecuario (Venezuela): Un estudio vincula el riesgo de malaria en los puntos críticos de deforestación con la demanda de productos agrícolas (07/Jun/2020)
Phys.Org (Reino Unido): Study links malaria risk in deforestation hotspots to demand for agricultural commodities (05/Jun/2020)
Elexonic: Study links malaria risk in deforestation hotspots to demand for agricultural commodities (05/Jun/2020)
7thSpace: Study links malaria risk in deforestation hotspots to demand for agricultural commodities (05/Jun/2020)
The Times of India (Índia) online: Study links malaria risk in deforestation hotspots to demand for agricultural commodities (05/Jun/2020)
NewsColony (Nigéria): Malaria risk in deforestation hotspots linked to demand for agricultural commodities (05/Jun/2020)
News Medical (Austrália): Malaria risk in deforestation hotspots linked to demand for agricultural commodities (04/Jun/2020)
Bioengineer (Reino Unido): Study links malaria risk in deforestation hotspots to demand for agricultural commodities (04/Jun/2020)
Science Codex: Study links malaria risk in deforestation hotspots to demand for agricultural commodities (04/Jun/2020)
Scienmag Science Magazine (Reino Unido): Study links malaria risk in deforestation hotspots to demand for agricultural commodities (04/Jun/2020)
Sound Health and Lasting Wealth (Nigéria): Malaria risk in deforestation hotspots linked to demand for agricultural commodities (04/Jun/2020)
Ciclo Vivo: Estudo relaciona desmatamento e commodities agrícolas com aumento de malária (28/May/2020)
Central das Notícias: Estudo relaciona desmatamento e commodities agrícolas com aumento de malária (28/May/2020)
Plantão News (MT): Estudo relaciona risco de malária em áreas de desmatamento à demanda por Commódities agrícolas (24/May/2020)
SenhorEco: Estudo Relaciona Risco de Malária em Áreas de Desmatamento à Demanda por 'Commodities' Agrícolas (23/May/2020)
Saber Atualizado: Estudo relaciona risco de malária em áreas de desmatamento à demanda por commodities agrícolas (22/May/2020)
Ambientebrasil: Estudo relaciona risco de malária em áreas de desmatamento à demanda por commodities agrícolas (21/May/2020)
Agrosoft: Estudo relaciona risco de malária em áreas de desmatamento à demanda por commodities agrícolas (21/May/2020)
Revista Amazônia: Estudo relaciona risco de malária em áreas de desmatamento à demanda por commodities agrícolas (21/May/2020)
Ecoamazônia: Estudo relaciona risco de malária em áreas de desmatamento à demanda por commodities agrícolas (21/May/2020)
JC Notícias (São Paulo, SP): Estudo relaciona risco de malária em áreas de desmatamento à demanda por commodities agrícolas (21/May/2020)
Espaço Ecológico no Ar: Consumo de café e chocolate em países ricos aumenta risco de malária no sul global (29/Mar/2020)
Dom Total: Consumo de café e chocolate em países ricos aumenta risco de malária no sul global (28/Mar/2020)
Planeta online: Consumo de café e chocolate em países ricos aumenta risco de malária no sul global (26/Mar/2020)
Jornal da USP online: Consumo de café e chocolate em países ricos aumenta risco de malária no sul global (24/Mar/2020)

Scientific publications (37)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHAVES, LEONARDO SUVEGES MOREIRA; BERGO, EDUARDO STERLINO; CONN, JAN E.; LAPORTA, GABRIEL ZORELLO; PRIST, PAULA RIBEIRO; SALLUM, MARIA ANICE MUREB. Anthropogenic landscape decreases mosquito biodiversity and drives malaria vector proliferation in the Amazon rainforest. PLoS One, v. 16, n. 1 JAN 14 2021. Web of Science Citations: 0.
NAGAKI, SANDRA SAYURI; CHAVES, LEONARDO S. M.; LOPEZ, ROSSANA VEONICA MENDOZA; BERGO, EDUARDO S.; LAPORTA, GABRIEL Z.; CONN, JAN E.; SALLUM, MARIA ANICE MUREB. Host feeding patterns of Nyssorhynchus darlingi (Diptera: Culicidae) in the Brazilian Amazon. Acta Tropica, v. 213, JAN 2021. Web of Science Citations: 0.
MUREB SALLUM, MARIA ANICE; OBANDO, RANULFO GONZALEZ; CARREJO, NANCY; WILKERSON, RICHARD C. Identification keys to the Anopheles mosquitoes of South America (Diptera: Culicidae). IV. Adult females. PARASITES & VECTORS, v. 13, n. 1 DEC 18 2020. Web of Science Citations: 2.
MUREB SALLUM, MARIA ANICE; OBANDO, RANULFO GONZALEZ; CARREJO, NANCY; WILKERSON, RICHARD C. Identification keys to the Anopheles mosquitoes of South America (Diptera: Culicidae). II. Fourth-instar larvae. PARASITES & VECTORS, v. 13, n. 1 DEC 18 2020. Web of Science Citations: 3.
HUTCHINGS, ROSA SA GOMES; HUTCHINGS, ROGER WILLIAM; MENEZES, ISIS SA; SALLUM, MARIA ANICE MUREB. Mosquitoes (Diptera: Culicidae) From the Southwestern Brazilian Amazon: Liberdade and Gregorio Rivers. Journal of Medical Entomology, v. 57, n. 6, p. 1793-1811, NOV 2020. Web of Science Citations: 0.
SALLUM, MARIA ANICE MUREB; OBANDO, RANULFO GONZALEZ; CARREJO, NANCY; WILKERSON, RICHARD C. Identification key to the Anopheles mosquitoes of South America (Diptera: Culicidae). III. Male genitalia. PARASITES & VECTORS, v. 13, n. 1 OCT 31 2020. Web of Science Citations: 2.
MASSAD, EDUARDO; LAPORTA, GABRIEL ZORELLO; CONN, JAN EVELYN; CHAVES, LEONARDO SUVEGES; BERGO, EDUARDO STERLINO; GUIMARAES FIGUEIRA, ELDER AUGUSTO; BEZERRA COUTINHO, FRANCISCO ANTONIO; LOPEZ, LUIS FERNANDEZ; STRUCHINER, CLAUDIO; MUREB SALLUM, MARIA ANICE. The risk of malaria infection for travelers visiting the Brazilian Amazonian region: A mathematical modeling approach. TRAVEL MEDICINE AND INFECTIOUS DISEASE, v. 37, SEP-OCT 2020. Web of Science Citations: 0.
OLIVEIRA, TATIANE MARQUES PORANGABA; SANABANI, SABRI SAEED; SALLUM, MARIA ANICE MUREB. Bacterial diversity associated with the abdomens of naturallyPlasmodium-infected and non-infectedNyssorhynchus darlingi. BMC Microbiology, v. 20, n. 1 JUN 25 2020. Web of Science Citations: 0.
DE SA, IVY LUIZI RODRIGUES; HUTCHINGS, ROSA SA GOMES; HUTCHINGS, ROGER WILLIAM; SALLUM, MARIA ANICE MUREB. Revision of the Atratus Group of Culex (Melanoconion) (Diptera: Culicidae). PARASITES & VECTORS, v. 13, n. 1 MAY 27 2020. Web of Science Citations: 0.
KIRCHGATTER, KARIN; DE OLIVEIRA GUIMARAES, LILIAN; YANEZ TRUJILLANO, HENRRY HUGO; RAFAEL ARIAS, FERNANDO; GERMAN CACERES, ABRAHAM; RIBEIRO DE CASTRO DUARTE, ANA MARIA; MALAFRONTE, ROSELY DOS SANTOS; TUBAKI, ROSA MARIA; MUREB SALLUM, MARIA ANICE. Phylogeny of Anopheles (Kerteszia) (Diptera: Culicidae) Using Mitochondrial Genes. INSECTS, v. 11, n. 5 MAY 2020. Web of Science Citations: 0.
CHAVES, LEONARDO SUVEGES MOREIRA; FRY, JACOB; MALIK, ARUNIMA; GESCHKE, ARNE; SALLUM, MARIA ANICE MUREB; LENZEN, MANFRED. Global consumption and international trade in deforestation-associated commodities could influence malaria risk. NATURE COMMUNICATIONS, v. 11, n. 1 MAR 9 2020. Web of Science Citations: 0.
DEMARI-SILVA, B.; LAPORTA, G. Z.; OLIVEIRA, T. M. P.; SALLUM, M. A. M. Plasmodium infection in Kerteszia cruzii (Diptera: Culicidae) in the Atlantic tropical rain forest, southeastern Brazil. INFECTION GENETICS AND EVOLUTION, v. 78, MAR 2020. Web of Science Citations: 0.
CHU, VIRGINIA M.; MUREB SALLUM, MARIA ANICE; MOORE, TIMOTHY E.; EMERSON, KEVIN J.; SCHLICHTING, CARL D.; CONN, JAN E. Evidence for family-level variation of phenotypic traits in response to temperature of Brazilian Nyssorhynchus darlingi. PARASITES & VECTORS, v. 13, n. 1 FEB 10 2020. Web of Science Citations: 0.
TATIANE M. P. OLIVEIRA; SABRI S. SANABANI; MARIA ANICE M. SALLUM. Asaia (Rhodospirillales: Acetobacteraceae) and Serratia (Enterobacterales: Yersiniaceae) associated with Nyssorhynchus braziliensis and Nyssorhynchus darlingi (Diptera: Culicidae). Revista Brasileira de Entomologia, v. 64, n. 2, p. -, 2020. Web of Science Citations: 0.
PIOVEZAN, RAFAEL; VISOCKAS, ALEXANDRE; DE AZEVEDO, THIAGO SALOMAO; VON ZUBEN, CLAUDIO JOSE; MUREB SALLUM, MARIA ANICE. Spatial-temporal distribution of Aedes (Stegomyia) aegypti and locations of recycling units in southeastern Brazil. PARASITES & VECTORS, v. 12, n. 1 NOV 14 2019. Web of Science Citations: 0.
PRUSSING, CATHARINE; EMERSON, KEVIN J.; BICKERSMITH, SARA A.; MUREB SALLUM, MARIA ANICE; CONN, JAN E. Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil. PLoS One, v. 14, n. 11 NOV 14 2019. Web of Science Citations: 2.
DE OLIVEIRA PADILHA, MEYRECLER AGLAIR; MELO, JANILLE DE OLIVEIRA; ROMANO, GUILHERME; MALVEIRA DE LIMA, MARCOS VINICIUS; ALONSO, WLADIMIR J.; MUREB SALLUM, MARIA ANICE; LAPORTA, GABRIEL ZORELLO. Comparison of malaria incidence rates and socioeconomic-environmental factors between the states of Acre and Rondonia: a spatio-temporal modelling study. Malaria Journal, v. 18, n. 1 SEP 4 2019. Web of Science Citations: 0.
SALLUM, MARIA ANICE M.; CONN, JAN E.; BERGO, EDUARDO S.; LAPORTA, GABRIEL Z.; CHAVES, LEONARDO S. M.; BICKERSMITH, SARA A.; DE OLIVEIRA, TATIANE M. P.; FIGUEIRA, ELDER AUGUSTO G.; MORESCO, GILBERTO; OLIVER, LEUDA; STRUCHINER, CLAUDIO J.; YAKOB, LAITH; MASSAD, EDUARDO. Vector competence, vectorial capacity of Nyssorhynchus darlingi and the basic reproduction number of Plasmodium vivax in agricultural settlements in the Amazonian Region of Brazil. Malaria Journal, v. 18, APR 4 2019. Web of Science Citations: 3.
GRENI, SUSAN ELAINE; DEMARI-SILVA, BRUNA; PORANGABA DE OLIVEIRA, TATIANE MARQUES; SUESDEK, LINCOLN; LAPORTA, GABRIEL ZORELLO; MUREB SALLUM, MARIA ANICE. A Multi-Gene Analysis and Potential Spatial Distribution of Species of the Strodei Subgroup of the Genus Nyssorhynchus (Diptera: Culicidae). Journal of Medical Entomology, v. 55, n. 6, p. 1486-1495, NOV 2018. Web of Science Citations: 0.
BOURKE, BRIAN P.; CONN, JAN E.; DE OLIVEIRA, TATIANE M. P.; CHAVES, LEONARDO S. M.; BERGO, EDUARDO S.; LAPORTA, GABRIEL Z.; SALLUM, MARIA A. M. Exploring malaria vector diversity on the Amazon Frontier. Malaria Journal, v. 17, SEP 27 2018. Web of Science Citations: 2.
MOREIRA CHAVES, LEONARDO SUVEGES; CONN, JAN E.; MENDOZA LOPEZ, ROSSANA VERONICA; MUREB SALLUM, MARIA ANICE. Abundance of impacted forest patches less than 5 km(2) is a key driver of the incidence of malaria in Amazonian Brazil. SCIENTIFIC REPORTS, v. 8, MAY 4 2018. Web of Science Citations: 15.
TORRES-GUTIERREZ, CAROLINA; DE OLIVEIRA, TATIANE M. P.; EMERSON, KEVIN J.; BERGO, EDUARDO STERLINO; MUREB SALLUM, MARIA ANICE. Molecular phylogeny of Culex subgenus Melanoconion (Diptera: Culicidae) based on nuclear and mitochondrial protein-coding genes. ROYAL SOCIETY OPEN SCIENCE, v. 5, n. 5 MAY 2018. Web of Science Citations: 0.
DE AZEVEDO, THIAGO S.; BOURKE, BRIAN PATRICK; PIOVEZAN, RAFAEL; SALLUM, MARIA ANICE M. The influence of urban heat islands and socioeconomic factors on the spatial distribution of Aedes aegypti larval habitats. GEOSPATIAL HEALTH, v. 13, n. 1, p. 179-187, 2018. Web of Science Citations: 2.
FOSTER, PETER G.; PORANGABA DE OLIVEIRA, TATIANE MARQUES; BERGO, EDUARDO S.; CONN, JAN E.; SANT'ANA, DENISE CRISTINA; NAGAKI, SANDRA SAYURI; NIHEI, SILVIO; LAMAS, CARLOS EINICKER; GONZALEZ, CHRISTIAN; MOREIRA, CAIO CESAR; MUREB SALLUM, MARIA ANICE. Phylogeny of Anophelinae using mitochondrial protein coding genes. ROYAL SOCIETY OPEN SCIENCE, v. 4, n. 11 NOV 2017. Web of Science Citations: 18.
DEMARI-SILVA, BRUNA; MULTINI, LAURA CRISTINA; SUESDEK, LINCOLN; OLIVEIRA, TATIANE M. P.; MUREB SALLUM, MARIA ANICE; MARRELLI, MAURO TOLEDO. Wing Morphometry and Genetic Variability Between Culex coronator and Culex usquatus (Diptera: Culicidae), Two Sibling Species of the Coronator Group. Journal of Medical Entomology, v. 54, n. 4, p. 901-908, JUL 2017. Web of Science Citations: 2.
MARTEIS, LETICIA SILVA; NATAL, DELSIO; MUREB SALLUM, MARIA ANICE; MEDEIROS-SOUSA, ANTONIO RALPH; PORANGABA OLIVEIRA, TATIANE MARQUES; LA CORTE, ROSELI. Mosquitoes of the Caatinga: 1. Adults stage survey and the emerge of seven news species endemic of a dry tropical forest in Brazil. Acta Tropica, v. 166, p. 193-201, FEB 2017. Web of Science Citations: 3.
DENISE CRISTINA SANT'ANA; MARIA ANICE MUREB SALLUM. Anopheles (Nyssorhynchus) striatus, a new species of the Strodei Subgroup (Diptera, Culicidae). Revista Brasileira de Entomologia, v. 61, n. 2, p. 136-145, Abr. 2017. Web of Science Citations: 1.
AMAKU, M.; AZEVEDO, F.; BURATTINI, M. N.; COELHO, G. E.; COUTINHO, F. A. B.; GREENHALGH, D.; LOPEZ, L. F.; MOTITSUKI, R. S.; WILDER-SMITH, A.; MASSAD, E. Magnitude and frequency variations of vector-borne infection outbreaks using the Ross-Macdonald model: explaining and predicting outbreaks of dengue fever. EPIDEMIOLOGY AND INFECTION, v. 144, n. 16, p. 3435-3450, DEC 2016. Web of Science Citations: 4.
RUFALCO-MOUTINHO, PAULO; SCHWEIGMANN, NICOLAS; BERGAMASCHI, DENISE PIMENTEL; MUREB SALLUM, MARIA ANICE. Larval habitats of Anopheles species in a rural settlement on the malaria frontier of southwest Amazon, Brazil. Acta Tropica, v. 164, p. 243-258, DEC 2016. Web of Science Citations: 7.
TORRES-GUTIERREZ, CAROLINA; BERGO, EDUARDO STERLINO; EMERSON, KEVIN J.; DE OLIVEIRA, TATIANE M. P.; GRENI, SUSAN; MUREB SALLUM, MARIA ANICE. Mitochondrial COI gene as a tool in the taxonomy of mosquitoes Culex subgenus Melanoconion. Acta Tropica, v. 164, p. 137-149, DEC 2016. Web of Science Citations: 8.
HUTCHINGS, R. S. G.; HUTCHINGS, R. W.; MENEZES, I. S.; MOTTA, M. DE A.; SALLUM, M. A. M. Mosquitoes (Diptera: Culicidae) From the Northwestern Brazilian Amazon: Padauari River. Journal of Medical Entomology, v. 53, n. 6, p. 1330-1347, NOV 2016. Web of Science Citations: 4.
NARANJO-DIAZ, NELSON; SALLUM, MARIA ANICE M.; CORREA, MARGARITA M. Population dynamics of Anopheles nuneztovari in Colombia. INFECTION GENETICS AND EVOLUTION, v. 45, p. 56-65, NOV 2016. Web of Science Citations: 4.
OLIVEIRA, T. M. P.; FOSTER, P. G.; BERGO, E. S.; NAGAKI, S. S.; SANABANI, S. S.; MARINOTTI, O.; MARINOTTI, P. N.; SALLUM, M. A. M. Mitochondrial Genomes of Anopheles (Kerteszia) (Diptera: Culicidae) From the Atlantic Forest, Brazil. Journal of Medical Entomology, v. 53, n. 4, p. 790-797, JUL 2016. Web of Science Citations: 3.
DEMARI-SILVA, BRUNA; FOSTER, PETER G.; DE OLIVEIRA, TATIANE M. P.; BERGO, EDUARDO S.; SANABANI, SABRI S.; PESSOA, RODRIGO; SALLUM, MARIA ANICE M. Mitochondrial genomes and comparative analyses of Culex camposi, Culex coronator, Culex usquatus and Culex usquatissimus (Diptera:Culicidae), members of the coronator group. BMC Genomics, v. 16, OCT 21 2015. Web of Science Citations: 9.
TORRES-GUTIERREZ, CAROLINA; MUREB SALLUM, MARIA ANICE. Catalog of the subgenus Melanoconion of Culex (Diptera: Culicidae) for South America. Zootaxa, v. 4028, n. 1, p. 1-50, OCT 7 2015. Web of Science Citations: 3.
MARTEIS, L. S.; SALLUM, M. A. M.; NATAL, D.; OLIVEIRA, T. M. P.; GAMA, R. A.; DOLABELLA, S. S.; SANTOS, R. L. C. First Record of Anopheles oryzalimnetes, Anopheles argyritarsis, and Anopheles sawyeri (Diptera: Culicidae) in the Caatinga Biome, Semiarid Scrubland of Sergipe State, Brazil. Journal of Medical Entomology, v. 52, n. 5, p. 858-865, SEP 2015. Web of Science Citations: 4.
LAPORTA, GABRIEL ZORELLO; LINTON, YVONNE-MARIE; WILKERSON, RICHARD C.; BERGO, EDUARDO STERLINO; NAGAKI, SANDRA SAYURI; SANT'ANA, DENISE CRISTINA; MUREB SALLUM, MARIA ANICE. Malaria vectors in South America: current and future scenarios. PARASITES & VECTORS, v. 8, AUG 19 2015. Web of Science Citations: 18.

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