Muscle oxidative stress, neurotoxicity and human health risks from consuming fish exposed to metallic settleable atmospheric particulate matter

Author(s)

Carvalho, Mariana V. ; Monteiro, Rafaella ; Souza, Iara da C. ; Griboff, Julieta ; Bendhack, Fabiano ; Monferran, Magdalena V. ; Wunderlin, Daniel A. ; Fernandes, Marisa N.

• Document type: Journal article
• Source: Marine Pollution Bulletin; v. 214, p. 15-pg., 2025-03-14.

Abstract

The concentration of metals/metalloids in settleable particulate matter (SePM) from industrial area and in the muscles were determined in the estuarine fish, Centropomus parallelus, after 96 h-exposure to different SePM concentrations. Antioxidant defenses, oxidative damage and neurotoxicity were also determined. The risk for human consumption was evaluated by estimating daily intake (EDI), target hazard quotient (THQ), and hazard index (HI) and compared with fish collected close to the industries. Eighteen metals/metalloids were quantified in SePM and the muscles. In red muscle, the antioxidant enzymes were unchanged, and the acetylcholinesterase (AChE) activity and protein carbonyls (PC) increased. In white muscle, the glutathione-S-transferase (GST) activity and glutathione content (GSH) decreased, PC levels and lipid peroxidation (LPO) increased; the AChE was unchanged. Metals/metalloids bioaccumulated in muscles induced oxidative damage which may affect muscle function and consequently, fish performance. After short-term exposure to SePM there was no risk for human consumption. However, the EDI of fish collected in field exceeded the acceptable DI for children concerning to As and Hg. HI were lower than 1 revealing no carcinogenic risk. (AU)

• FAPESP's process: 19/08491-0 - Atmospheric particulate material and environmental contamination. Impact assessment in the aquatic biota in an integrated ecophysiotoxicological approach
• Grantee: Marisa Narciso Fernandes
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 23/01356-5 - Incorporation of metallic nanoparticles present in atmospheric particullate matter in tissues of Centropomus parallelus and Oreochromis niloticus
• Grantee: Marisa Narciso Fernandes
• Support Opportunities: Regular Research Grants