| Full text | |
| Author(s): |
de Macedo, Brunno Gilberto Santos
;
de Melo, Manuela Albuquerque
;
Pereira-Martins, Diego Antonio
;
Machado-Neto, Joao Agostinho
;
Traina, Fabiola
Total Authors: 5
|
| Document type: | Journal article |
| Source: | BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER; v. 1880, n. 4, p. 10-pg., 2025-09-01. |
| Abstract | |
The tumor microenvironment plays an important role in cancer onset and progression. Its significance has been increasingly addressed in myeloid neoplasms. Such a shift marks a departure from the usual tumor-centered approach to a more comprehensive and integrated understanding of the interplay between myeloid tumors and their surroundings. On this note, we aimed to summarize, in this review, an up-to-date take on how a pro-inflammatory milieu influences clonal selection of genetically altered hematopoietic stem cells towards myeloid malignancies at the expense of their healthy counterpart; the role of NLRP3 inflammasome, a major component of the innate immunity and source of interleukin-1 beta, over acute myeloid leukemia development and performance; and, alongside post-translational modifications, how autophagy represents a major NLRP3 inflammasome regulator. (AU) | |
| FAPESP's process: | 23/09514-9 - Investigation of mitochondrial metabolism in the biology of myelodysplastic syndrome |
| Grantee: | Manuela Albuquerque de Melo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 22/03871-1 - Functional and molecular investigation of the correlation between autophagy, NLRP3-inflammasome and hemostasis on acute myeloid leukemia |
| Grantee: | Brunno Gilberto Santos de Macedo |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 13/08135-2 - CTC - Center for Cell-Based Therapy |
| Grantee: | Dimas Tadeu Covas |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 14/50947-7 - INCT 2014: in Stem Cell and Cell Therapy |
| Grantee: | Dimas Tadeu Covas |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/11112-0 - Assessment of autophagy as a therapeutic efficiency limiting mechanism of FLT3 pharmacological inhibitors on acute myeloid leukemia |
| Grantee: | Manuela Albuquerque de Melo |
| Support Opportunities: | Scholarships in Brazil - Master |