Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers

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de Lima-Souza, Reydson Alcides ; Goncalves, Moises Willian Aparecido ; de Sa, Raisa Sales ; Lavareze, Luccas ; Scarini, Joao Figueira ; Kimura, Talita de Carvalho ; Ribeiro, Fernanda Cristina Poscai ; Altemani, Albina ; Mariano, Fernanda Viviane ; Fillmore, Gary Chris ; Abu Egal, Erika Said

• Document type: Journal article
• Source: FRONTIERS IN ONCOLOGY; v. 15, p. 9-pg., 2025-05-12.

Abstract

The Eph (erythropoietin-producing hepatocellular carcinoma) receptor family represents the largest subgroup within the tyrosine kinase receptor family and is recognized for its critical role in regulating the growth, migration, and survival of both normal and malignant cells. The Eph/ephrin signaling has an ambiguous role in squamous cell carcinomas of the oral region, playing both a suppressive and oncogenic role. In salivary gland cancers, the results are reserved, although they suggest that some molecules are associated with a worse prognosis for patients. This review offers a comprehensive summary of the existing literature, underscoring the evidence that supports the involvement of the Eph/ephrin signaling in oral and maxillofacial cancers. Additionally, we examine molecular discoveries that may present promising therapeutic targets for these malignancies. (AU)

• FAPESP's process: 23/14770-4 - DNA content analysis of different histological subtypes and epidemiological groups of head and neck squamous cell carcinomas and their association to the tumor microenvironment
• Grantee: Moisés Willian Aparecido Gonçalves
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 20/08431-4 - METABOLOMIC PROFILING ANALYSIS IN THE MALIGNANT TRANSFORMATION OF PLEOMORPHIC ADENOMA
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/11861-6 - Comparative analysis of Adenoid Cystic Carcinoma exome in xenograft model with and without entinostat and cisplatin therapy
• Grantee: Luccas Lavareze dos Reis
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 23/13091-6 - ANALYSIS OF miRNAs EXPRESSION AND POTENTIAL TARGETS IN THE MALIGNANT TRANSFORMATION OF PLEOMORPHIC ADENOMA
• Grantee: Talita de Carvalho Kimura
• Support Opportunities: Scholarships in Brazil - Doctorate