| Full text | |
| Author(s): |
Magalhães, Danielle A. R.
[1]
;
Macedo, Claudia
;
Junta, Cristina M.
;
Mello, Stephano S.
;
Marques, Márcia M. C.
;
Cardoso, Renato S.
;
Sakamoto-Hojo, Elza T.
;
Donadi, Eduardo A.
;
Passos, Geraldo A. S.
Total Authors: 9
|
| Affiliation: | [1] Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto. - Brasil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Molecular Immunology; v. 42, n. 9, p. 1043-1048, May 2005. |
| Field of knowledge: | Biological Sciences - Immunology |
| Abstract | |
Non-manipulated inbred mouse strains constitutes an interesting model-system for in vivo studies on thymus ontogeny due to the possibility to observe the molecular events of the thymocyte maturation. In previous studies, using RT-PCR method, we have found that several immune system genes such as interleukins and MHC are differentially expressed during ontogeny of the thymus whose genes act as modulators of T-cell differentiation. To determine which other genes are modulated on a large-scale basis, we measured the levels of mRNA expression in mouse fetal thymus (14-17 days of gestation) by hybridization with cDNA microarrays containing 1,576 cDNA sequences derived from the IMAGE MTB library...(AU) | |
| FAPESP's process: | 99/12135-9 - Transcriptome project: large scale gene expression analysis using DNA-Arrays |
| Grantee: | Geraldo Aleixo da Silva Passos Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |