| Full text | |
| Author(s): |
Orsi, Juan B.
;
Scariot, Pedro P. M.
;
Polisel, Emanuel E. C.
;
Araujo, Lara S.
;
Santos, Matheus R.
;
Papoti, Marcelo
;
Manchado-Gobatto, Fulvia B.
;
Gobatto, Claudio A.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY; v. N/A, p. 14-pg., 2025-06-06. |
| Abstract | |
Researchers have extensively studied how hypoxia affects physiological variables, with training models like "live high - train low" (LH-TL) proposed by Levine & Stray-Gundersen in 1997 to improve athletic performance. Although well-known, few studies use animal models for more in-depth analyses than human studies allow. This study investigated the effects of aerobic training on adiposity, spontaneous physical activity (SPA), and food and water intake in C57BL/6J mice housed in normoxic (Nx) or hypoxic (Hx) conditions for 8 weeks. Mice were divided into trained (T) and sedentary (S) groups, with 10 mice each. Hx animals were kept in normobaric hypoxia (FiO2=14.5%) for 18 h/day. Training was done at 80% critical velocity, 5 times/week in normoxia. The T groups had lower SPA, especially the Hx-T group, which showed higher food and water intake, reduced fat, and a higher fat-free mass/carcass fat mass ratio. Findings suggest exercise and hypoxia may help combat obesity. (AU) | |
| FAPESP's process: | 24/04688-1 - EFFECTS OF THE "LIVE HIGH - TRAIN LOW" TRAINING MODEL ON HEMATIMETRIC, BIOMOLECULAR AND BIOCHEMICAL RESPONSES ASSOCIATED WITH ENERGY BALANCE |
| Grantee: | Juan Bordon Orsi |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/05115-7 - Effects of aerobic training and the hypoxic environment on molecular responses related to anaerobic and aerobic metabolism and acid-base properties in the hypothalamus and skeletal muscle of mice |
| Grantee: | Pedro Paulo Menezes Scariot |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/10201-4 - Effects of aerobic physical training and the availability of wide space housing on the spontaneous physical activity, central and peripheral metabolic and molecular responses |
| Grantee: | Claudio Alexandre Gobatto |
| Support Opportunities: | Regular Research Grants |