The intelligent podocyte: sensing and responding to a complex microenvironment

Author(s)

Bertram, John F. ; Cullen-McEwen, Luise A. ; Andrade-Oliveira, Vinicius ; Camara, Niels Olsen Saraiva

• Document type: Journal article
• Source: NATURE REVIEWS NEPHROLOGY; v. 21, n. 7, p. 14-pg., 2025-05-08.

Abstract

Podocytes are key components of the glomerular filtration barrier - a specialized structure that is responsible for the filtration of blood by the kidneys. They therefore exist in a unique microenvironment exposed to mechanical force and the myriad molecules that cross the filtration barrier. To survive and thrive, podocytes must continually sense and respond to their ever-changing microenvironment. Sensing is achieved by interactions with the surrounding extracellular matrix and neighbouring cells, through a variety of pathways, to sense changes in environmental factors such as nutrient levels including glucose and lipids, oxygen levels, pH and pressure. The response mechanisms similarly involve a range of processes, including signalling pathways and the actions of specific organelles that initiate and regulate appropriate responses, including alterations in cell metabolism, immune regulation and changes in podocyte structure and cognate functions. These functions ultimately affect glomerular and kidney health. Imbalances in these processes can lead to inflammation, podocyte loss and glomerular disease. (AU)

• FAPESP's process: 19/14755-0 - Shaping gut microbiota and immune system by the intestinal epithelial cells: from tissue homeostasis to diseases
• Grantee: Vinicius de Andrade Oliveira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 23/07482-2 - Sensing extra and intracellular stressors by renal and immune cells: new insights into signal reception and transduction, and their relevance for understanding renal diseases
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants