Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis

Author(s)

Mendes, Eduardo ; Umana, Evelyn Roxana Perez ; Penna, Daniel Di Pace Soares ; de Oliveira, Fernando Augusto ; Lemos, Leandro Nascimento ; Ribeiro, Willian Rodrigues ; Casaro, Mateus Barbosa ; Lazarini, Mariana ; Oliveira, Valeria Maia ; Ferreira, Caroline Marcantonio

• Document type: Journal article
• Source: MICROORGANISMS; v. 13, n. 5, p. 21-pg., 2025-05-07.

Abstract

Recent studies have emphasized the impact of gut microbiota on skin health, but the reverse, how skin diseases affect gut homeostasis, has received less attention. Allergic contact dermatitis (ACD), a common skin disorder affecting one in four people worldwide, can be accompanied by intestinal disturbances. To explore this, we used an experimental model of ACD to investigate the intestinal changes induced by the disease. Parameters assessed included intestinal microbiota, short-chain fatty acids (SCFAs), gene expression related to intestinal permeability, inflammatory cytokines, and mucus production. To evaluate potential therapeutic interventions, the probiotic Bifidobacterium longum strain BB536 was administered via gavage, starting 10 days before dermatitis induction and continuing until the last day of disease induction. ACD caused alterations in the composition of intestinal microbiota compared to na & iuml;ve mice but did not affect SCFA production. The probiotic altered microbiota composition and increased acetate production in dermatitis-induced mice. ACD decreased the gene expression of TjP1, ATHO1, and MUC2, while probiotic treatment restored TjP1 and ATHO1 to normal levels. The cytokine IL-6 increased in the ACD group compared to na & iuml;ve mice, whereas IL-10 decreased; probiotic treatment also restored these levels. Intestinal mucus production, affected by ACD, was partially restored by probiotic treatment. The findings suggest that probiotics could be a therapeutic strategy to prevent intestinal issues caused by skin diseases. (AU)

• FAPESP's process: 22/08144-0 - Multi-user equipment approved in grant 21/06751-4: BD FACSymphony A1 Cell Analyzer
• Grantee: Caroline Marcantonio Ferreira
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 19/12324-1 - Probiotic as a therapeutic tool in the skin-lung-bowel axis
• Grantee: Caroline Marcantonio Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 24/13576-2 - Lung-Brain Axis: A Potential Pathway for the Development of Dementia.
• Grantee: Fernando Augusto de Oliveira Ribeiro
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 12/50410-8 - Effects of short-chain fatty acids produced by probiotic bacteria in the prophylaxis and treatment of allergic airway inflammation
• Grantee: Caroline Marcantonio Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/06751-4 - Deciphering the immune mechanism of increased airway allergic disease in menopause
• Grantee: Caroline Marcantonio Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2