| Full text | |
| Author(s): |
Rosenbusch, Ivo
;
Arai, Marylyn Setsuko
;
Rizzo, Fabio
;
de Camargo, Andrea S. S.
;
Ravoo, Bart Jan
Total Authors: 5
|
| Document type: | Journal article |
| Source: | NANOSCALE ADVANCES; v. 7, n. 13, p. 10-pg., 2025-05-27. |
| Abstract | |
Herein, we present a pH-sensitive nanoplatform based on Tm3+/Yb3+ co-doped upconversion nanoparticles (UCNPs) functionalized with beta-cyclodextrin (beta-CD) and a pH-responsive nitrobenzoxadiazole dye modified with adamantane (NBD-Ad). The host-guest interaction between beta-CD on the UCNP surface and Ad on NBD-Ad enables a stable, water-dispersible ratiometric pH sensor. Upon 980 nm excitation, the UCNPs emit in the UV and blue regions, which overlap with the pH-dependent absorption of NBD-Ad. This overlap induces selective quenching of UV and blue emissions via inner filter effect (IFE). The red emission (650 nm) remains stable and is used as an internal reference for ratiometric sensing. The sensor shows a ratiometric response (blue/red) over a pH range of 8.0-11.0 with high reproducibility. The nanoplatform demonstrates excellent reusability and selectivity even in the presence of interferents. (AU) | |
| FAPESP's process: | 22/07233-0 - Chemical and biological sensors based on upconversion nanoparticles: From surface functionalization to devices |
| Grantee: | Emanuel Carrilho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07793-6 - CeRTEV - Center for Research, Technology and Education in Vitreous Materials |
| Grantee: | Edgar Dutra Zanotto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 24/05979-0 - Biomimetic luminescent nanoparticles based on cell-membrane coating for glioblastoma theranostics. |
| Grantee: | Marylyn Setsuko Arai |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/12588-9 - Optical biosensors for the fast detection of pathogenic bacteria |
| Grantee: | Marylyn Setsuko Arai |
| Support Opportunities: | Scholarships in Brazil - Doctorate |