Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium

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Cabral-Marques, Otavio ; Schimke, Lena F. ; Moll, Guido ; Filgueiras, Igor Salerno ; Nobile, Adriel Leal ; Adri, Anny Silva ; do Vale, Fernando Yuri Nery ; Usuda, Julia Nakanishi ; Correa, Yohan Lucas Gonsalves ; Albuquerque, Debora ; Nava, Roseane Galdioli ; Santos, Ronaldy Santana ; Dias, Haroldo Dutra ; Silva, Helio Fernandes ; Marconi, Pedro Batista ; Catari, Rusan ; Adu-Gyamfii, Michael ; Wang, Pinchao ; Khan, Taj Ali ; Hackel, Alexander M. ; Leheis, Anja ; Staehle, Anja ; Mueller, Antje ; Schmidt, Carolin ; Radunovic, Chiara ; Adjailia, El-Baraa ; Grasshoff, Hanna ; Humrich, Jens Y. ; Menz, Jonas ; Fourlakis, Konstantinos ; Winziers, Maike ; Japel, Maj ; Wegner, Manuel Vincent ; Lamprecht, Peter ; Nieberding, Relana ; Akbarzadeh, Reza ; Arnold, Sabrina ; Jendrek, Sebastian ; Klapa, Sebastian ; Augustin, Solveig ; Biedermann, Sophie ; Schinke, Susanne ; Scheererm, Patrick ; Endres, Matthias ; Schulze-Forster, Kai ; Paul, Friedemann ; Yu, Xinhua ; Sotzny, Franziska ; Sakmar, Thomas P. ; Banasik, Miroslaw ; Haghikia, Aiden ; Hoffmann, Markus H. ; Veprintsev, Dmitry ; Witte, Torsten ; Dalmolin, Rodrigo J. S. ; Ochs, Hans D. ; Heidecke, Harald ; Scheibenbogen, Carmen ; Shoenfeld, Yehuda ; Riemekasten, Gabriela

• Document type: Journal article
• Source: AUTOIMMUNITY REVIEWS; v. 24, n. 9, p. 13-pg., 2025-08-29.

Abstract

The 5th International Symposium on Regulatory Autoantibodies Targeting GPCR (RAB-GPCRs) advanced the understanding of the significant role played by autoantibodies targeting G-protein-coupled receptors (GPCRs) in various human diseases. Once considered passive markers, RAB-GPCRs are now recognized as active modulators of cellular signaling, immune regulation, and inflammation. The symposium highlighted their involvement in multiple prominent pathologies, including autoimmune diseases, cardio-and cerebrovascular diseases, and neuroimmunologic disorders such as myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 syndrome (ME/CFS/PCS), as well as solid organ and hematopoietic stem cell transplantation (SOT/HSCT). Experts from rheumatology, immunology, and neurology presented interdisciplinary discussions on the potential of RAB-GPCRs as biomarkers and therapeutic targets. Advances in screening methods, biomarker identification, and therapeutic strategies were shared, emphasizing their diagnostic potential and application in novel therapeutic interventions. This report summarizes key insights from the symposium, particularly focusing on the modulatory properties of RAB-GPCRs and their relevance in both immune-mediated diseases and other pathologies (e.g., vascular, degenerative) that are traditionally not considered primarily immune-mediated. Ongoing research is expected to further establish these autoantibodies as crucial components in disease modulation and systems biology contexts, offering new opportunities for precision medicine and improved clinical outcomes in immune-related disorders. (AU)

• FAPESP's process: 23/07806-2 - Integrative systems bioinformatics analysis of antiviral immune responses.
• Grantee: Igor Salerno Filgueiras
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
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• Grantee: Júlia Nakanishi Usuda
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
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• Grantee: Anny Silva Adri
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/18886-9 - Systemic and integrative analysis of the immune response to Zika and Dengue viral infections
• Grantee: Otávio Cabral Marques
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 24/08016-8 - Systemic integrative analysis of the network of molecules associated with neuroimmune dysregulation induced by viral hepatitis.
• Grantee: Adriel Leal Nóbile
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
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• Grantee: Dennyson Leandro Mathias da Fonseca
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)