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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis

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Author(s):
Mendes, Mariana Trivilin [1, 2] ; Murari-do-Nascimento, Stephanie [1] ; Torrigo, Isis Rossetti [1] ; Alponti, Rafaela Fadoni [1] ; Yamasaki, Simone Cristina [1] ; Silveira, Paulo Flavio [1]
Total Authors: 6
Affiliation:
[1] Inst Butantan, Pharmacol Lab, BR-05503900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Physiol, Inst Biociencias, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Regulatory Peptides; v. 167, n. 2-3, p. 215-221, APR 11 2011.
Web of Science Citations: 4
Abstract

The objective of this study was to investigate the catalytic activity of basic aminopeptidase (APB) and its association with periarticular edema and circulating tumor necrosis factor (TNF)-alpha and type II collagen (CII) antibodies (AACII) in a rat model of rheumatoid arthritis (RA) induced by CII (CIA). Edema does not occur in part of CH-treated, even when AACII is higher than in control. TNF-alpha is detectable only in edematous CII-treated. APB in synovial membrane is predominantly a membrane-bound activity also present in soluble form and with higher activity in edematous than in non-edematous CH-treated or control. Synovial fluid and blood plasma have lower APB in non-edematous than in edematous CII-treated or control. In peripheral blood mononuclear cells (PBMCs) the highest levels of APB are found in soluble form in control and in membrane-bound form in non-edematous CII-treated. CII treatment distinguishes two categories of rats: one with arthritic edema, high AACII, detectable TNF-alpha, high soluble and membrane-bound APB in synovial membrane and low APB in the soluble fraction of PBMCs, and another without edema and with high AACII, undetectable TNF-alpha, low APB in the synovial fluid and blood plasma and high APB in the membrane-bound fraction of PBMCs. Data suggest that APB and CIA are strongly related. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/17613-0 - Basic aminopeptidase (APB) and leukotriene-a4-hydrolase (LTA4H) in the plasma, synovia and synovium of rats sensitive and insensitive to induction of arthritis by type-II collagen
Grantee:Paulo Flávio Silveira
Support Opportunities: Regular Research Grants