| Full text | |
| Author(s): Show less - |
Lima, Maria Leticia Duarte
;
Sanches, Paulo Ricardo da Silva
;
Geraldini, Dayla Bott
;
Ayusso, Gabriela Miranda
;
da Conceicao, Pamela Joyce Previdelli
;
Carvalho, Tamara
;
Gonzalez, Jorge Enrique Hernandez
;
Gismene, Carolina
;
Bittar, Cintia
;
Arni, Raghuvir Krishnaswamy
;
Cilli, Eduardo Maffud
;
Calmon, Marilia de Freitas
;
Rahal, Paula
Total Authors: 13
|
| Document type: | Journal article |
| Source: | VIROLOGY; v. 611, p. 12-pg., 2025-07-29. |
| Abstract | |
Zika virus (ZIKV) is an emerging arbovirus, and its infection is often asymptomatic or mild; however, it can lead to severe neurological disorders. Currently, there are no approved treatments or vaccines for ZIKV, highlighting the urgent need to explore potential therapeutic options. In this study, we evaluated the antiviral activity of a novel synthetic peptide (GA-peptide) against ZIKV in vitro. The GA-peptide exhibited dose-dependent inhibition of the virus, affecting multiple stages of the ZIKV replication cycle. It demonstrated virucidal activity and effectively protected Vero cells from ZIKV infection. Additionally, the GA-peptide disrupted viral entry by targeting both the attachment and internalization phases, as well as post-entry stages of the infection. In silico analyses identified potential viral targets that interact with the GA-peptide. These findings underscore the GApeptide's promising potential as a therapeutic agent against ZIKV and its relevance in the development of new antiviral drugs. (AU) | |
| FAPESP's process: | 22/03901-8 - Computer-guided identification of inhibitors against staphylococcal exfoliative toxins |
| Grantee: | Jorge Enrique Hernández González |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 23/02956-6 - In vitro evaluation of peptides and bioconjugates against Chikungunya Virus (CHIKV) and utilization of murine model for assessing the efficacy and toxicity of hit compounds |
| Grantee: | Paulo Ricardo da Silva Sanches |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 23/04491-0 - Searching for peptide ligands for proteases from Zika, Yellow Fever, Chikungunya and Mayaro arboviruses using Phage Display |
| Grantee: | Dayla Bott Geraldini |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 24/00876-8 - Protein exosites, cryptic sites and moonlighting: identification, functional mapping and effects of changes in structure |
| Grantee: | Carolina Gismene |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/07784-3 - In vitro study of the action of synthetic peptides as antivirals against CHIKV |
| Grantee: | Marilia de Freitas Calmon |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 24/13327-2 - Integrating Protein Flexibility into Machine Learning Models for Virtual Hit Identification |
| Grantee: | Jorge Enrique Hernández González |
| Support Opportunities: | Scholarships in Brazil - Support Program for Fixating Young Doctors |
| FAPESP's process: | 20/05761-3 - Study of the action of synthetic peptides as antivirals against SARS-CoV-2 (COVID-19) and combined evaluation with commercial anti-inflammatories |
| Grantee: | Eduardo Maffud Cilli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/05411-8 - Development of peptide/guanidine bioconjugates with anti-Leishmania activity |
| Grantee: | Eduardo Maffud Cilli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/08615-8 - Protein exosites, cryptic sites and moonlighting: identification, functional mapping and effects of changes in structure |
| Grantee: | Raghuvir Krishnaswamy Arni |
| Support Opportunities: | Research Projects - Thematic Grants |