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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytotoxic Clerodane Diterpenes from Casearia rupestris

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Author(s):
Vieira-Junior, Gerardo M. [1] ; Dutra, Luiz A. [1] ; Ferreira, Paulo M. P. [2] ; de Moraes, Manoel O. [3] ; Lotufo, Leticia V. Costa [3] ; Pessoa, Claudia do O. [3] ; Torres, Roseli Buzanelli [4] ; Boralle, Nivaldo [1] ; Bolzani, Vanderlan da S. [1] ; Cavalheiro, Alberto J. [1]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ, UNESP, Inst Chem, Nucley Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-14801970 Araraquara, SP - Brazil
[2] Univ Fed Piaui, UFPI, Dept Ciencias Saude, BR-64600000 Picos, PI - Brazil
[3] Univ Fed Ceara, Dept Fisiol & Farmacol, Lab Oncol Expt LOE, BR-60430270 Fortaleza, Ceara - Brazil
[4] Inst Agron Campinas, Nucleo Jardim Bot, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Natural Products; v. 74, n. 4, p. 776-781, APR 2011.
Web of Science Citations: 28
Abstract

Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6), All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Caseartipestrin A (1) exhibited the most potent activity against MDA/MB-435 (human Melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug:doxorubicin. (AU)

FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants