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Infra-specific chemical variability and dynamics of phenolic and diterpenic secondary metabolites in Casearia Sylvestris SW (Salicaceae) from different Brazilian ecosystems: metabolomics and proteomics correlation

Grant number: 11/21440-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): August 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Alberto José Cavalheiro
Grantee:Paula Carolina Pires Bueno
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):12/21921-4 - Proteomics of two varieties of Casearia Sylvestris SW. (Salicaceae), BE.EP.DR


The species Casearia sylvestris Sw (Salicaceae) is an important representative of the Casearia Jacq. genus, due to its chemical, pharmacological, economic, environmental and biotechnological aspects. Because of its high adaptive capacity, this species is widespread in Central and South America and, in Brazil, it occurs in practically all biomes. The morpho-anatomical, chemical and genetic data available on C. sylvestris, indicate close relationship between the variety "lingua" and the Cerrado biome, and between the variety "sylvestris" and Atlantic Forest. Also, there are data describing significant genetic differences between these two varieties. In ecotones Cerrado/Atlantic Forest, it can be found these two varieties, including individuals with intermediate characteristics, considering both morpho-anatomical and genetic ones. There is evidence that in C. sylvestris var. "lingua"/Cerrado occur predominantly the phenolic compounds, while in C. sylvestris var. "sylvestris"/Atlantic Forest the clerodane diterpenes predominate. So, taking part in the thematic network CECAA - "Prospecção de moléculas bioativas e estudo de variabilidade infra-específica em plantas e microrganismos endofíticos do Cerrado e Caatinga - Contribuição para o conhecimento e uso sustentável da biodiversidade brasileira." (CNPq 563311/2010-0 and FAPESP 2010/52327-5), the main objective of this project is to evaluate the hypothesis that the chemical composition, considering the secondary metabolites, is related to and / or conditioned by biomes, and mainly associated to their predominant morphotypes and, therefore, under strong genetic control. If this hypothesis is proven, individuals with differential production of clerodane diterpenes (type casearinas) can be used for comparative proteomic studies aiming the identification of enzymes related to the biosynthesis of these important metabolites.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, SABRINA M.; FRATUCELLI, ERICK D. O.; BUENO, PAULA C. P.; DE CASTRO, V, MARLENE KELLY; FRANCISCO, AMANDA ALCALA; CAVALHEIRO, ALBERTO JOSE; KLEIN, I, MARLISE. Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 19, n. 1 NOV 12 2019. Web of Science Citations: 0.
PIRES BUENO, PAULA CAROLINA; PASSARELI, FERNANDO; ANHESINE, NAIRA BUZZO; TORRES, ROSELI BUZANELLI; CAVALHEIRO, ALBERTO JOSE. Flavonoids from Casearia sylvestris Swartz variety lingua (Salicaceae). Biochemical Systematics and Ecology, v. 68, p. 23-26, OCT 2016. Web of Science Citations: 3.

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