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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes

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Author(s):
Bueno, Paula Carolina Pires [1] ; Salome Abarca, Luis Francisco [2] ; Anhesine, Naira Buzzo [1] ; Giffoni, Maira Silva [1] ; Pereira, Fabiola Manhas Verbi [1, 3] ; Torres, Roseli Buzaneli [4] ; de Sousa, Rayran Walter Ramos [5] ; Ferreira, Paulo Michel Pinheiro [5] ; Pessoa, Claudia [6] ; Cavalheiro, Alberto Jose [1]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Biochem & Organ Chem, Inst Chem, Rua Prof Francisco Degni 55, BR-14800900 Araraquara, SP - Brazil
[2] Leiden Univ, Inst Biol, Nat Prod Lab, Leiden - Netherlands
[3] Natl Inst Alternat Technol Detect Toxicol Assessm, Araraquara, SP - Brazil
[4] Herbarium IAC, Agron Inst Campinas, Campinas, SP - Brazil
[5] Univ Fed Piaui, Lab Expt Cancerol, Dept Biophys & Physiol, Teresina, PI - Brazil
[6] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, Fortaleza, CE - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Planta Medica; v. 87, n. 01/02 DEC 2020.
Web of Science Citations: 0
Abstract

Casearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua . Despite the existence of data about their chemical composition, a deeper understanding of the specialized metabolism correlation and variation in respect to environmental factors and its repercussion over their biological activities was still pending. In this study, an UHPLC-DAD-based metabolomics approach was employed for the investigation of the chemical variation of 12 C. sylvestris populations sampled across 4 Brazilian biomes and ecotones. The correlation between infraspecific chemical variability and the cytotoxic and antioxidant activities was achieved by multivariate data analysis. The analyses showed that C. sylvestris var. lingua prevailed at Cerrado areas, and it was correlated with lower cytotoxic activity and high level of glycosylated flavonoids. Among them, narcissin and isorhamnetin-3- O-alpha -L-rhamnopyranosyl-(1 -> 2)- alpha -L-arabinopyranoside showed good correlation with the antioxidant activity. Conversely, C. sylvestris var. sylvestris prevailed at the Atlantic Forest areas, and it was associated with high cytotoxic activity and high content of clerodane diterpenoids. Different casearins showed good correlation ( R (2) =0.3-0.70) with the cytotoxic activity. These findings highlighted the great complexity among different C. sylvestris populations, their chemical profile, and the related biological activities. Consequently, it can certainly influence the medicinal properties, as well as the quality and efficacy, of C. sylvestris phytomedicines. (AU)

FAPESP's process: 16/20295-3 - International PSE Symposium - Plant Omics and Biotechnology for Human Health
Grantee:Paula Carolina Pires Bueno
Support type: Research Grants - Meeting - Abroad
FAPESP's process: 12/21921-4 - Proteomics of two varieties of Casearia Sylvestris SW. (Salicaceae)
Grantee:Paula Carolina Pires Bueno
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/21440-3 - Infra-specific chemical variability and dynamics of phenolic and diterpenic secondary metabolites in Casearia sylvestris Sw (Salicaceae) from different Brazilian ecosystems: metabolomics and proteomics correlation
Grantee:Paula Carolina Pires Bueno
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 19/01102-8 - Multi-user equipament approved in grant 2018/18212-8: X-Ray Fluorescence spectrometer
Grantee:Fabíola Manhas Verbi Pereira
Support type: Multi-user Equipment Program
FAPESP's process: 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies
Grantee:Maria Valnice Boldrin
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/02738-0 - Chemical documentation of species from Casearia genus (Salicaceae) of ecological, economical and medicinal relevance
Grantee:Naira Buzzo Anhesine
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/18212-8 - Development of chemometric models for determination of solid impurities in raw sugarcane using energy dispersive X-ray fluorescence
Grantee:Fabíola Manhas Verbi Pereira
Support type: Regular Research Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC