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Proteomics of two varieties of Casearia Sylvestris SW. (Salicaceae)

Grant number: 12/21921-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): December 18, 2012
Effective date (End): June 17, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Alberto José Cavalheiro
Grantee:Paula Carolina Pires Bueno
Supervisor abroad: Michael Hippler
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Local de pesquisa : University of Munster, Germany  
Associated to the scholarship:11/21440-3 - Infra-specific chemical variability and dynamics of phenolic and diterpenic secondary metabolites in Casearia sylvestris Sw (Salicaceae) from different Brazilian ecosystems: metabolomics and proteomics correlation, BP.DR


Proteomics is a fundamental technique in the field of the "omics" science, complementing information obtained by the genomic, transcriptomic and metabolomic approaches. The main aim is the study of proteins expressed in a biological system, under certain developmental stage or environmental conditions. Since proteins are the final product of gene expression, indicating the physiological state of an organism, it is expected from this study and, using computational tools for data integration, to understand the chemical and molecular modulation of the phenotype of species in its natural habitat, considering both biotic and abiotic stresses. For the species Casearia sylvestris Sw (Salicaceae) are recognized two varieties. The variety C. sylvestris sylvestris is mainly characterized by the production of clerodane type diterpenes (casearins) and the variety C. sylvestris lingua produces, unlike the first, mainly phenolic compounds. However, despite the existence of data concerning the chemical composition of these two varieties, as well as some information about the morphological and genetic profile, nothing is known about the profile of the expressed proteins. For this reason, as originally proposed, one of the goals of this project is to apply proteomic studies in order to understand the biosynthetic routes used by the species C. sylvestris using individuals with differentiated production of clerodane type diterpenes (casearins) and phenolic compounds. It is expected to advance in the knowledge of the proteic profile of a brazilian native species, and to integrate this data with already known data about their chemical, genetic and morphological profile, considering the important ecological variability existing. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, SABRINA M.; FRATUCELLI, ERICK D. O.; BUENO, PAULA C. P.; DE CASTRO, V, MARLENE KELLY; FRANCISCO, AMANDA ALCALA; CAVALHEIRO, ALBERTO JOSE; KLEIN, I, MARLISE. Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 19, n. 1 NOV 12 2019. Web of Science Citations: 0.

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