Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-L-cysteine

Author(s)

Abbehausen, Camilla ^[1] ; Heinrich, Tassiele A. ^[2] ; Abrao, Emiliana P. ^[2] ; Costa-Neto, Claudio M. ^[2] ; Lustri, Wilton R. ^[3] ; Formiga, Andre L. B. ^[1] ; Corbi, Pedro P. ^[1]

Affiliation

^[1] Univ Estadual Campinas UNICAMP, Inst Quim, BR-13083970 Campinas, SP - Brazil

^[2] FMRP USP, Dept Bioquim & Imunol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Ctr Univ Araraquara UNIARA, Assoc Sao Bento Ensino, Dept Ciencias Biol & Saude, BR-14801320 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Polyhedron; v. 30, n. 4, p. 579-583, MAR 11 2011.
• Web of Science Citations: 19

Abstract

A new silver(I) complex with N-acetyl-t-cysteine (NAC) of composition AgC(5)H(8)NO(3)S center dot H(2)O was synthesized and characterized by a set of chemical and spectroscopic measurements. Solid-state (13)C nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Ag(I) through the sulfur atom. The Ag-NAC complex is slightly soluble in dimethyl sulfoxide. It is insoluble in water, methanol, ethanol, acetone and hexane. Antibacterial activity of the silver complex with N-acetyl-t-cysteine (Ag-NAC) was evaluated by antibiogram assays using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coil and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for evaluation of a potential cytotoxic effect of Ag-NAC was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a significant cytotoxic activity, inducing 80% of cell death at a concentration of 200 mu mol L(-1). (C) 2010 Elsevier Ltd. All rights reserved. (AU)