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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

No deleterious effect of low dose methotrexate on titanium implant osseointegration in a rabbit model

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Author(s):
Carvas, Janaina Badin [1] ; Rodrigues Pereira, Rosa Maria [1] ; Bonfa, Eloisa [1] ; Silveira, Celey Aparecida [1] ; Lima, Luiz Lapa [2] ; Caparbo, Valeria de Falco [1] ; Verissimo de Mello, Suzana Beatriz [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Div Rheumatol, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dent Branch, BR-05508 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Clinics; v. 66, n. 6, p. 1055-1059, 2011.
Web of Science Citations: 2
Abstract

OBJECTIVE: To evaluate the effect of low dose methotrexate alone or in combination with glucocorticoid treatment on titanium implant osseointegration. METHODS: Groups of 6-8 adult New Zealand White rabbits were treated for 18 weeks with saline (control), methotrexate, glucocorticoid, or methotrexate plus glucocorticoid. The animals received a titanium implant in the tibia at week 6. Lumbar spine and tibia bone mineral densities were analyzed before and after treatment. Histomorphometric analysis of bone cortical thickness, total bone area around the implant, and % of bone to implant contact was performed. RESULTS: After 18 weeks, the change in the bone mineral density in the lumbar spines and tibias in the methotrexate group was comparable to the control group (0.035 vs. 0.055 g/cm² and 0.021 vs. 0.041 g/cm², respectively). In contrast, both the glucocorticoid group and glucocorticoid plus methotrexate group had significant reductions at both sites. Histomorphometric analysis of the tibia in the control and methotrexate groups revealed no significant changes in cortical thickness (133 vs. 126 μm), total bone area around the implant (33 vs. 30%), or bone to implant contact (40 vs. 38%). In contrast, glucocorticoid group had significant reductions compared to controls in tibia cortical thickness (99 vs. 133 μm), total bone area around the implant (24 vs. 33%), and bone to implant contact (27 vs. 40%). Similar reductions were observed in the glucocorticoid plus methotrexate group. CONCLUSIONS: Our results demonstrate that low dose methotrexate treatment does not affect titanium implant osseointegration, suggesting that this therapy is safe for surgical procedures requiring a titanium implant. (AU)