Synthesis, spectroscopic characterization, and antibacterial assays in vitro of a new platinum(II) complex with methionine sulfoxide

Author(s)

Castello, W. S. ^[1] ; Spera, M. B. M. ^[1] ; Gomes, A. F. ^[1] ; Gozzo, F. C. ^[1] ; Lustri, W. R. ^[2] ; Formiga, A. L. B. ^[1] ; Corbi, P. P. ^[1]

Affiliation

^[1] Univ Estadual Campinas UNICAMP, Inst Quim, BR-13083970 Campinas, SP - Brazil

^[2] Associacao Sao Bento de Ensino, Ctr Univ Araraquara UNIARA, BR-14801320 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Journal of Coordination Chemistry; v. 64, n. 2, p. 272-280, 2011.
• Web of Science Citations: 2

Abstract

A new platinum(II) complex with methionine sulfoxide was synthesized and characterized by chemical and spectroscopic techniques. Elemental analyses, mass spectrometric measurements (electrospray ionization quadrupole time-of-flight mass spectrometry), and thermal analyses of the solid compound fit the composition {[}(C(5)H(10)NO(3)S)Pt(mu-Cl)(2)Pt(C(5)H(10)NO(3)S)]center dot 2.5H(2)O. Infrared spectroscopic data indicate coordination of the ligand to Pt(II) through the nitrogen of NH(2) and the sulfur of the S=O group. (1)H-(15)N nuclear magnetic resonance spectroscopic data confirm nitrogen coordination. Antibacterial activities were evaluated by antibiogram assays using the disc diffusion method. The platinum(II) complex showed antibacterial activity against Gram-negative Pseudomonas aeruginosa bacterial cells. (AU)

• FAPESP's process: 10/00534-7 - Metal complexes with methionine sulfoxide: synthesis, characterization and biological applications.
• Grantee: Wellington Seixas Castello
• Support Opportunities: Scholarships in Brazil - Scientific Initiation