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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibodies to ribosomal P proteins in lupus nephritis: A surrogate marker for a better renal survival?

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Author(s):
de Macedo, Patricia Andrade ; Borba, Eduardo Ferreira ; Trindade Viana, Vilma dos Santos ; Leon, Elaine Pires ; Testagrossa, Leonardo de Abreu [1] ; Barros, Rui Toledo [2] ; Nascimento, Ana Patricia ; Bonfa, Eloisa [3]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Pathol, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Div Nephrol, BR-01246903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Div Rheumatol, Fac Med, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: AUTOIMMUNITY REVIEWS; v. 10, n. 3, p. 126-130, JAN 2011.
Web of Science Citations: 19
Abstract

Objective: To define if antibodies to ribosomal P proteins disclose a better lupus nephritis long-term survival. Methods: Sixty consecutive SLE patients with biopsy-proven nephritis (2004 ISN/RPS) were evaluated for renal survival parameters. Inclusion criteria were at least one serum sample at: renal flares, biopsy, and last follow-up until 2008. Anti-P was detected by ELISA/immunoblot and anti-dsDNA by indirect immunofluorescence/ELISA. Results: Eleven patients (18%) with anti-P+ (without anti-dsDNA) during renal flare were compared to 49 (82%) persistently negative for anti-P throughout the study. At the final follow-up post-biopsy (6.3 +/- 2.5 vs. 6.8 +/- 2.4 years, p = 0.36), the comparison of anti-P+/anti-dsDNA with anti-P group revealed a trend to lower mean creatinine levels (0.9 +/- 0.3 vs. 2.3 +/- 2.1 mg/dl, p = 0.07), lower frequency of dialysis (0% vs. 35%, p = 0.025), and higher frequency of normal renal function (91% vs. 53%, p = 0.037). The overall renal survival was significantly higher in anti-P+/anti-dsDNA compared to anti-P (11.0 +/- 4.5 vs. 9.2 +/- 4.5 years, p = 0.033), anti-dsDNA+/anti-P (vs. 8.7 +/- 4.7 years, p = 0.017), and anti-P /anti-dsDNA (vs. 9.8 +/- 4.3 years, p = 0.09) groups. Conclusion: Our data supports the notion that anti-P antibody in the absence of anti-dsDNA during nephritis flares is a valuable marker to predict a better long-term renal outcome in lupus patients. (C) 2010 Elsevier B.V. All rights reserved. (AU)