| Full text | |
| Author(s): |
Trevilatto, Paula C.
[1]
;
de Souza Pardo, Ana Paula
[2]
;
Scarel-Caminaga, Raquel M.
[3]
;
de Brito, Jr., Rui B.
[4]
;
Alvim-Pereira, Fabiano
[1]
;
Alvim-Pereira, Claudia C.
[1]
;
Probst, Christian M.
[5]
;
Garlet, Gustavo P.
[6]
;
Sallum, Antonio W.
[2]
;
Line, Sergio R. P.
[2]
Total Authors: 10
|
| Affiliation: | [1] Pontifical Catholic Univ Parana PUCPR, Ctr Hlth & Biol Sci, BR-80215901 Curitiba, Parana - Brazil
[2] Univ Estadual Campinas, Dent Sch Piracicaba, Dept Morphol, Piracicaba, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Sch Dent, Dept Diag & Surg, Araraquara, SP - Brazil
[4] Sao Leopoldo Mand Dent Res Inst, Campinas, SP - Brazil
[5] Fiocruz MS, Chagas Inst ICC, Curitiba, Parana - Brazil
[6] Sao Paulo Univ FOB USP, Sch Dent Bauru, Dept Biol Sci, Bauru, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | ARCHIVES OF ORAL BIOLOGY; v. 56, n. 1, p. 54-62, JAN 2011. |
| Web of Science Citations: | 33 |
| Abstract | |
Chronic periodontal disease (PD) is an infectious immune-inflammatory illness. Polymorphisms in IL1 genes play a role in inflammatory diseases through the modulation of cytokine levels. Objective: This study aimed to investigate the association between polymorphisms in the IL1 gene cluster and chronic periodontitis in a Brazilian population. Design: A sample of 113 subjects over 25 years (mean age 41.2) were grouped into: 44 healthy individuals, 31 subjects with moderate and 38 with severe periodontitis. DNA was obtained through a mouthwash and oral mucosa scraping. PCR-RFLP was used to identify the following polymorphisms: ILIA C - 889T (rs1800587), IL1B C - 511T (rs16944), IL1B C + 3954T (rs11436340), IL1RN intron 2 (rs2234663). Differences in the allele/genotype/haplotype frequencies were assessed by Chi-square test (p < 0.05). The risk associated with alleles, genotypes and haplotypes was calculated as odds ratio (OR) with 95% confidence intervals (CI). Results: Neither ILIA (C - 889T) nor IL1B (C + 3954T) polymorphisms was associated with chronic PD. Allele T for IL1B (C - 511T) only associated with PD in the group of blacks and mulattos. Moreover, genotype 2/2 for IL1RN (intron 2) was associated with severe PD. Conclusions: Genotype 2/2 of IL1RN for the whole Brazilian population and allele T of IL1B (C - 511T) in a subgroup of Afro-Americans and mulattos were suggested as putative risk indicators for chronic periodontitis. (C) 2010 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 99/05610-2 - Suscetibilidade genetica a severidade da doenca periodontal em adultos em familias com periodontite de inicio precoce. |
| Grantee: | Sergio Roberto Peres Line |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 99/06094-8 - Suscetibilidade genética a severidade da doença periodontal em adultos e em famílias com periodontite de início precoce |
| Grantee: | Paula Cristina Trevilatto |
| Support Opportunities: | Scholarships in Brazil - Doctorate |