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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians

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Author(s):
Trevilatto, Paula C. [1] ; de Souza Pardo, Ana Paula [2] ; Scarel-Caminaga, Raquel M. [3] ; de Brito, Jr., Rui B. [4] ; Alvim-Pereira, Fabiano [1] ; Alvim-Pereira, Claudia C. [1] ; Probst, Christian M. [5] ; Garlet, Gustavo P. [6] ; Sallum, Antonio W. [2] ; Line, Sergio R. P. [2]
Total Authors: 10
Affiliation:
[1] Pontifical Catholic Univ Parana PUCPR, Ctr Hlth & Biol Sci, BR-80215901 Curitiba, Parana - Brazil
[2] Univ Estadual Campinas, Dent Sch Piracicaba, Dept Morphol, Piracicaba, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Sch Dent, Dept Diag & Surg, Araraquara, SP - Brazil
[4] Sao Leopoldo Mand Dent Res Inst, Campinas, SP - Brazil
[5] Fiocruz MS, Chagas Inst ICC, Curitiba, Parana - Brazil
[6] Sao Paulo Univ FOB USP, Sch Dent Bauru, Dept Biol Sci, Bauru, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 56, n. 1, p. 54-62, JAN 2011.
Web of Science Citations: 33
Abstract

Chronic periodontal disease (PD) is an infectious immune-inflammatory illness. Polymorphisms in IL1 genes play a role in inflammatory diseases through the modulation of cytokine levels. Objective: This study aimed to investigate the association between polymorphisms in the IL1 gene cluster and chronic periodontitis in a Brazilian population. Design: A sample of 113 subjects over 25 years (mean age 41.2) were grouped into: 44 healthy individuals, 31 subjects with moderate and 38 with severe periodontitis. DNA was obtained through a mouthwash and oral mucosa scraping. PCR-RFLP was used to identify the following polymorphisms: ILIA C - 889T (rs1800587), IL1B C - 511T (rs16944), IL1B C + 3954T (rs11436340), IL1RN intron 2 (rs2234663). Differences in the allele/genotype/haplotype frequencies were assessed by Chi-square test (p < 0.05). The risk associated with alleles, genotypes and haplotypes was calculated as odds ratio (OR) with 95% confidence intervals (CI). Results: Neither ILIA (C - 889T) nor IL1B (C + 3954T) polymorphisms was associated with chronic PD. Allele T for IL1B (C - 511T) only associated with PD in the group of blacks and mulattos. Moreover, genotype 2/2 for IL1RN (intron 2) was associated with severe PD. Conclusions: Genotype 2/2 of IL1RN for the whole Brazilian population and allele T of IL1B (C - 511T) in a subgroup of Afro-Americans and mulattos were suggested as putative risk indicators for chronic periodontitis. (C) 2010 Elsevier Ltd. All rights reserved. (AU)