Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Recurrent sores by ill-fitting dentures and intra-oral squamous cell carcinoma in smokers

Full text
Author(s):
Vaccarezza, Gabriela Fuerst [1] ; Ferreira Antunes, Jose Leopoldo [2] ; Michaluart-Junior, Pedro [2]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Fac Odontol, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF PUBLIC HEALTH DENTISTRY; v. 70, n. 1, p. 52-57, WIN 2010.
Web of Science Citations: 12
Abstract

Objectives: To examine whether denture use and recurrent sores caused by ill-fitting dentures are associated with intra-oral squamous cell carcinoma (IO-SCC) in individuals exposed to tobacco. Methods: We conducted a hospital-based case-control study. The study population comprised 124 patients with IO-SCC and the same number of controls (individually paired according to gender and age) recruited from outpatient units of the same hospital. Conditional logistic regression analysis assessed the effect of denture use and recurrent oral sores by ill-fitting dentures, adjusted by covariates on the lifetime exposure to alcohol and tobacco, socioeconomic standings, and dietary patterns. Results: The use of dentures showed no association with IO-SCC {[}adjusted odds ratio (OR) 1.40, 95 percent confidence interval 0.51-3.87, P = 0.513] in an assessment controlled by socioeconomic position, lifetime exposure to alcohol and tobacco, and dietary patterns. However, the report of recurrent sores caused by ill-fitting dentures showed significant association with the disease (adjusted OR 4.58, 95 percent confidence interval 1.52-13.76, P = 0.007). Conclusions: The association between recurrent oral sores caused by ill-fitting dentures and squamous cell carcinoma of the mouth in smokers is in agreement with the hypothesis that the chronic physical irritation of oral mucosa contributes to the topical carcinogenic effect of tobacco, which must be taken into careful consideration in the planning of dental services for adults and the elderly. (AU)

FAPESP's process: 05/03367-6 - Conditions of mouth status and oral cancer
Grantee:Gabriela Furst Vaccarezza
Support Opportunities: Scholarships in Brazil - Master