Genetic damage in multiple organs of acutely exercised rats

Author(s)

Pozzi, Renan ^[1] ; Rosa, Jose C. ^[2] ; Eguchi, Ricardo ^[2] ; Oller do Nascimento, Claudia M. ^[2] ; Oyama, Lila M. ^{[1, 2]} ; Aguiar, Jr., Odair ^[1] ; Chaves, Marcelo D. ^[1] ; Ribeiro, Daniel A. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, BR-11060001 Santos, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, BR-11060001 Santos, SP - Brazil

• Document type: Journal article
• Source: Cell Biochemistry and Function; v. 28, n. 8, p. 632-636, DEC 2010.
• Web of Science Citations: 10

Abstract

The aim of this study was to investigate the effects of acute exercise on genomic damage in an animal model. Male adult Wistar rats were divided into the following groups: control and acute exercised (experimental). For this purpose, 15 animals were accustomed to running on a rodent treadmill for 15 min per day for 5 days (10-20 m min(-1); 08 grade). After 4 days at rest, active animals ran on the treadmill (22 m min(-1), 58 grade) till exhaustion. Cells from peripheral blood, liver, heart, and brain were collected after 0, 2, and 6 h after exercise. The results showed that acute exercise was able to induce genetic damage in peripheral blood cells after 2 and 6 h of exercise, whereas liver pointed out genetic damage for all periods evaluated. No genetic damage was induced either in brain or in heart cells. In conclusion, our results suggest that acute exercise could contribute to the genetic damage in peripheral blood and liver cells. It seems that liver is a sensitive organ to the genotoxic insult after acute exercise. Copyright (C) 2010 John Wiley \& Sons, Ltd. (AU)

• FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
• Grantee: Daniel Araki Ribeiro
• Support Opportunities: Research Grants - Young Investigators Grants