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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CASE-CONTROL STUDY ON PROGNOSTIC FACTORS IN ORAL SQUAMOUS CELL CARCINOMA IN YOUNG PATIENTS

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Author(s):
Kaminagakura, Estela [1] ; Vartanian, Jose Guilherme [1] ; da Silva, Sabrina Daniela [1] ; dos Santos, Carlos Roberto [2] ; Kowalski, Luiz Paulo [1]
Total Authors: 5
Affiliation:
[1] AC Camargo Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
[2] Hosp Canc Barretos, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 32, n. 11, p. 1460-1466, NOV 2010.
Web of Science Citations: 14
Abstract

Background. Oral squamous cell carcinoma affects mainly patients between the fifth and sixth decades of life, being rare in the young (<= 40 years old). Methods. Demographic, clinical, and pathologic features, and the long-term survival of 125 patients younger than 41 years of age were compared with 250 control patients older than 50 years old. Data were submitted to Kaplan-Meier and log-rank tests. Results. The percentage of nonsmokers was higher in the younger patients (p = .04). In the younger patients, tumors at advanced clinical stage (p < .01) and poorly differentiated tumors (p = .01) were associated with a higher risk of recurrence. The relapse rate was higher in the younger patients (p = .02); however, there was no significant difference on overall survival (p = .86). The younger patients diagnosed after the 1990s had less advanced clinical stage tumors, had an increase in the use of combination of surgery, radiotherapy, and chemotherapy, and their overall survival was improved. Conclusion. This study emphasizes the importance of early diagnosis and aggressive treatment of oral squamous cell car-cinoma. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1460-1466, 2010 (AU)

FAPESP's process: 07/56117-2 - Clinicopathological and molecular aspects of oral squamous cell carcinoma in patients aged less than or equal to 40 years
Grantee:Luiz Paulo Kowalski
Support Opportunities: Regular Research Grants