| Full text | |
| Author(s): |
Santos Coelho, Fernando Morgadinho
[1, 2]
;
Pradella-Hallinan, Marcia
[1]
;
Pedrazzoli, Mario
[1]
;
Senne Soares, Carlos Augusto
[2]
;
Peres Fernandes, Gustavo Bruniera
[2]
;
Goncalves, Andre Leite
[2]
;
Tufik, Sergio
[1]
;
Azeredo Bittencourt, Lia Rita
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Israelita Albert Einstein Hosp, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Arquivos de Neuro-Psiquiatria; v. 68, n. 5, p. 712-715, OCT 2010. |
| Web of Science Citations: | 8 |
| Abstract | |
This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at Sao Paulo, Brazil. Method: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1(star)0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level: Normal (N) - Hypocretin-1 higher than 110pg/m1 and Lower (L) Hypocretin-1 lower than 110 pg/ml. Results: Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p=0.0002). Discussion: This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1(star)0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1(star)0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy. (AU) | |
| FAPESP's process: | 98/14303-3 - Center for Sleep Studies |
| Grantee: | Sergio Tufik |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |