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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tissue Reaction to Silver Nanoparticles Dispersion as an Alternative Irrigating Solution

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Author(s):
Gomes-Filho, Joao Eduardo [1] ; Silva, Fernando Oliveira [1] ; Watanabe, Simone [1] ; Angelo Cintra, Luciano Tavares [1] ; Tendoro, Karina Vanessa [1] ; Dalto, Luana Godoy [1] ; Pacanaro, Sara Vieira [1] ; Lodi, Carolina Simonetti [1] ; Ferreira de Melo, Fernanda Fragoso [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, Aracatuba Sch Dent, Dept Endodont, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ENDODONTICS; v. 36, n. 10, p. 1698-1702, OCT 2010.
Web of Science Citations: 26
Abstract

Introduction: Nanomaterials have been used to create new consumer products as well as applications for life sciences and biotechnology. The aim of this study was to evaluate the tissue response to implanted polyethylene tubes filled with fibrin sponge embedded with silver nanoparticles dispersion. Methods: Thirty rats received individually 4 polyethylene tubes filled with sponge embedded in 47 ppm, 23 ppm silver nanoparticles dispersion, 2.5% sodium hypochlorite, or with no embedding as control. The observation periods were 7, 15, 30, 60, and 90 days. After each period of time, 6 animals were killed, and the tubes and surrounding tissue were removed, fixed, and prepared to be analyzed in light microscope with glycol methacrylate embedding, 3-mu m serial cutting, and hematoxylineosin stain. Qualitative and quantitative evaluations of the reactions were performed. Results: Both materials caused moderate reactions at 7 days. The response was similar to the control on the 15th day with 23 ppm silver nanoparticles dispersion and 2.5% sodium hypochlorite and on the 30th day with 47 ppm silver nanoparticles dispersion. Conclusions: It was possible to conclude that silver nanoparticles dispersion was biocompatible especially in a lower concentration. (J Endod 2010;36:1698-1702) (AU)

FAPESP's process: 09/16069-4 - Evaluation of the tissue response to silver nanoparticles
Grantee:Fernando Oliveira Silva
Support Opportunities: Scholarships in Brazil - Scientific Initiation