Effect of goniothalamin on the development of Ehrlich solid tumor in mice

Author(s)

Vendramini-Costa, Debora Barbosa ^{[1, 2, 3]} ; Daltro de Castro, Ilton Barros ^[1] ; Tasca Gois Ruiz, Ana Lucia ^[3] ; Marquissolo, Cilene ^[1] ; Pilli, Ronaldo Aloise ^{[1, 2]} ; de Carvalho, Joao Ernesto ^{[2, 3]}

Affiliation

^[1] Univ Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Programa Posgrad Biol Celular & Estrutural, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Div Farmacol & Toxicol, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr CP, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Bioorganic & Medicinal Chemistry; v. 18, n. 18, p. 6742-6747, SEP 15 2010.
• Web of Science Citations: 40

Abstract

In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself. (c) 2010 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action
• Grantee: Ronaldo Aloise Pilli
• Support Opportunities: Research Projects - Thematic Grants