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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of goniothalamin on the development of Ehrlich solid tumor in mice

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Author(s):
Vendramini-Costa, Debora Barbosa [1, 2, 3] ; Daltro de Castro, Ilton Barros [1] ; Tasca Gois Ruiz, Ana Lucia [3] ; Marquissolo, Cilene [1] ; Pilli, Ronaldo Aloise [1, 2] ; de Carvalho, Joao Ernesto [2, 3]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Programa Posgrad Biol Celular & Estrutural, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Div Farmacol & Toxicol, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr CP, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry; v. 18, n. 18, p. 6742-6747, SEP 15 2010.
Web of Science Citations: 40
Abstract

In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself. (c) 2010 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action
Grantee:Ronaldo Aloise Pilli
Support Opportunities: Research Projects - Thematic Grants