| Full text | |
| Author(s): |
Russo, Thiago L.
[1]
;
Peviani, Sabrina M.
[1]
;
Durigan, Joao L. Q.
[1]
;
Gigo-Benato, Davilene
[1]
;
Delfino, Gabriel B.
[1]
;
Salvini, Tania F.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Phys Therapy, BR-13565905 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY; v. 31, n. 1, p. 45-57, JUL 2010. |
| Web of Science Citations: | 25 |
| Abstract | |
Denervation causes muscle atrophy and incapacity in humans. Although electrical stimulation (ES) and stretching (St) are commonly used in rehabilitation, it is still unclear whether they stimulate or impair muscle recovery and reinnervation. The purpose of this study was to evaluate the effects of ES and St, alone and combined (ES + St), on the expression of genes that regulate muscle mass (MyoD, Runx1, atrogin-1, MuRF1 and myostatin), on muscle fibre cross-sectional area and excitability, and on the expression of the neural cell adhesion molecule (N-CAM) in denervated rat muscle. ES, St and ES + St reduced the accumulation of MyoD, atrogin-1 and MuRF1 and maintained Runx1 and myostatin expressions at normal levels in denervated muscles. None of the physical interventions prevented muscle fibre atrophy or N-CAM expression in denervated muscles. In conclusion, although ES, St and ES + St changed gene expression, they were insufficient to avoid muscle fibre atrophy due to denervation. (AU) | |
| FAPESP's process: | 08/03499-8 - The effect of anterior cruciate ligament rupture in morphology, gene and protein expressions related to atrophy in the quadriceps femoral muscle of rats |
| Grantee: | Gabriel Borges Delfino |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 08/09408-4 - The effect of electric stimulation in quadriceps femoris muscle atrophy after anterior cruciate ligament injury in rats |
| Grantee: | João Luiz Quagliotti Durigan |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 08/05237-0 - Possible efects of joint inflammation on skeletal muscle gene expression and morphology |
| Grantee: | Thiago Luiz de Russo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 07/03160-8 - The electrical stimulation and stretching in the treatment of denervated skeletal muscle: implications to the rehabilitation |
| Grantee: | Tania de Fatima Salvini |
| Support Opportunities: | Regular Research Grants |