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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of respiratory pressure support on hemodynamics and exercise tolerance in patients with COPD

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Oliveira, Cristino Carneiro [1] ; Carrascosa, Claudia Regina [1] ; Borghi-Silva, Audrey [1, 2] ; Berton, Danilo C. [1] ; Queiroga, Jr., Fernando [1] ; Ferreira, Eloara M. V. [1] ; Nery, Luiz E. [1] ; Neder, J. Alberto [1]
Total Authors: 8
[1] Univ Fed Sao Paulo, Paulista Sch Med UNIFESP EPM, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp Dis, Dept Med, BR-04020050 Sao Paulo - Brazil
[2] Fed Univ Sao Carlos UFSCar, Dept Phys Therapy, Pulm Physiotherapy Lab, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 109, n. 4, p. 681-689, JUL 2010.
Web of Science Citations: 14

Inspiratory pressure support (IPS) plus positive end-expiratory pressure (PEEP) ventilation might potentially interfere with the ``central{''} hemodynamic adjustments to exercise in patients with chronic obstructive pulmonary disease (COPD). Twenty-one non- or mildly-hypoxemic males (FEV(1) = 40.1 +/- A 10.7% predicted) were randomly assigned to IPS (16 cmH(2)O) + PEEP (5 cmH(2)O) or spontaneous ventilation during constant-work rate (70-80% peak) exercise tests to the limit of tolerance (T (lim)). Heart rate (HR), stroke volume (SV), and cardiac output (CO) were monitored by transthoracic cardioimpedance (Physioflow (TM), Manatec, France). Oxyhemoglobin saturation was assessed by pulse oximetry (SpO(2)). At similar SpO(2), IPS(16) + PEEP(5) was associated with heterogeneous cardiovascular effects compared with the control trial. Therefore, 11 patients (Group A) showed stable or increased Delta ``isotime{''} - rest SV {[}5 (0-29) mL], lower Delta HR but similar Delta CO. On the other hand, Delta SV {[}-10 (-15 to -3) mL] and Delta HR were both lower with IPS(16) + PEEP(5) in Group B (N = 10), thereby reducing Delta CO (p < 0.05). Group B showed higher resting lung volumes, and T (lim) improved with IPS(16) + PEEP(5) only in Group A {[}51 (-60 to 486) vs. 115 (-210 to 909) s, respectively; p < 0.05]. We conclude that IPS(16) + PEEP(5) may improve SV and exercise tolerance in selected patients with advanced COPD. Impaired SV and CO responses, associated with a lack of enhancement in exercise capacity, were found in a sub-group of patients who were particularly hyperinflated at rest. (AU)