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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High Throughput Simultaneous Assay of Atenolol and Chlortalidone in Combined Dose Tablets by Liquid Chromatography and Capillary Zone Electrophoresis

Author(s):
Patto, Daniela C. S. [1] ; Leite, Heitor O. A. [1] ; Tavares, Vanessa F. [1] ; Almeida, Mariana M. [1] ; Lima, Cibele R. R. C. [1] ; Alves, Joao M. P. [1] ; Prado, Maria S. A. [1] ; Hackmann, Erika R. M. K. [1] ; Santoro, Maria Ines R. M. [1] ; Singh, Anil K. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, BR-05315970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Latin American Journal of Pharmacy; v. 29, n. 4, p. 594-601, JUN 2010.
Web of Science Citations: 0
Abstract

New fast liquid chromatographic and capillary zone electrophoresis methods were developed and validated for simultaneous determination of atenolol and chlortalidone in combined dose tablets. The reversed phase HPLC method was carried out on a CN LiChrosorb (R) (125 x 4 mm, 5 mu m) column. The CZE method was carried out on an uncoated fused-silica capillary of 30 cm x 75 mu m i.d. with 25 mmol L(-1) sodium tetraborate, pH 9.4. The total analysis time was <6 and <2.5 min for HPLC and CZE methods, respectively. Both methods can be used for stability studies as well. (AU)