| Full text | |
| Author(s): |
Yasuda, Clarissa Lin
;
Betting, Luiz Eduardo
;
Cendes, Fernando
[1]
Total Authors: 3
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Neurol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | EXPERT REVIEW OF NEUROTHERAPEUTICS; v. 10, n. 6, p. 975-984, JUN 2010. |
| Web of Science Citations: | 23 |
| Abstract | |
Voxel-based morphometry is an automated technique for MRI analyses, developed to study differences in brain morphology and frequently used to study patients with diverse disorders. In epilepsy, it has been used to investigate areas with reduction or increase of gray and white matter, in different syndromes (i.e., temporal lobe epilepsy, focal cortical dysplasia and generalized epilepsies). In temporal lobe epilepsy, voxel-based morphometry showed gray/white matter atrophy extending beyond the atrophic hippocampus. These widespread abnormalities have been associated with seizure frequency, epilepsy duration, incidence of precipitating factors, cognitive dysfunction and surgical outcome. In generalized epilepsies, gray matter abnormalities were identified mainly in the thalamus and frontal cortex, reinforcing the role of the thalamocortical network in the mechanisms of generalized seizures. (AU) | |
| FAPESP's process: | 05/56578-4 - Multimodal neuroimaging center for studies in epilepsy |
| Grantee: | Fernando Cendes |
| Support Opportunities: | Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants |