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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Abnormal Neurovascular Control in Anabolic Androgenic Steroids Users

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Nazare Nunes Alves, Maria Janieire ; Dos Santos, Marcelo Rodrigues ; Dias, Rodrigo Goncalves ; Akiho, Cesar Abreu ; Laterza, Mateus Camaroti ; Pinto Brandao Rondon, Maria Urbana ; De Moraes Moreau, Regina Lucia [1] ; Negrao, Carlos Eduardo [2, 3]
Total Authors: 8
[1] Univ Sao Paulo, Coll Pharmaceut Sci, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05403000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Unidade Reabilitacao Cardiovasc & Fisiol Exercici, Sch Med, InCor, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 42, n. 5, p. 865-871, MAY 2010.
Web of Science Citations: 18

NUNES ALVES, M. J. N., M. R. DOS SANTOS, R. G. DIAS, C. A. AKIHO, M. C. LATERZA, M. U. P. B. RONDON, R. L. DE MORAES MOREAU, and C. E. NEGRAO. Abnormal Neurovascular Control in Anabolic Androgenic Steroids Users. Med. Sci. Sports Exerc., Vol. 42, No. 5, pp. 865-871, 2010. Purpose: Previous studies showed that anabolic androgenic steroids (AAS) increase vascular resistance and blood pressure (BP) in humans. In this study, we tested the hypotheses 1) that AAS users would have increased muscle sympathetic nerve activity (MSNA) and reduced forearm blood flow (FBF) compared with AAS nonusers and 2) that there would be an association between MSNA and 24-h BP. Methods: Twelve AAS users aged 31 +/- 2 yr (means +/- SE) and nine age-matched AAS nonusers aged 29 T 2 yr participated in the study. All individuals were involved in strength training for at least 2 yr. AAS was determined by urine test (chromatography-mass spectrometry). MSNA was directly measured by microneurography technique. FBF was measured by venous occlusion plethysmography. BP monitoring consisted of measures of BP for 24 h. Results: MSNA was significantly higher in AAS users than that in AAS nonusers (29 +/- 3 vs 20 +/- 1 bursts per minute, P = 0.01). FBF (1.92 +/- 0.17 vs 2.77 +/- 0.24 mL.min(-1).100 mL(-1), P = 0.01) and forearm vascular conductance (2.01 +/- 0.17 vs 2.86 +/- 0.31 U, P = 0.02) were significantly lower in AAS users than that in AAS nonusers. Systolic (131 +/- 4 vs 120 +/- 3 mm Hg, P = 0.001), diastolic (74 +/- 4 vs 68 +/- 3 mm Hg, P = 0.02), and mean BP (93 +/- 4 vs 86 +/- 3 mm Hg, P = 0.005) and heart rate (74 +/- 3 vs 68 +/- 3 bpm, P = 0.02) were significantly higher in AAS users when compared with AAS nonusers. Further analysis showed that there was a significant correlation between MSNA and 24-h mean BP (r = 0.75, P = 0.002). Conclusions: AAS increases MSNA and reduces muscle blood flow in young individuals. In addition, the increase in BP levels in AAS users is associated with augmented sympathetic outflow. These findings suggest that AAS increases the susceptibility for cardiovascular disease in humans. (AU)

FAPESP's process: 05/59740-7 - Physical exercise and autonomic control in cardiovascular physiopathology
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants