| Full text | |
| Author(s): Show less - |
da Silva, Natal S.
[1]
;
da Silva-Nunes, M.
[1, 2]
;
Malafronte, Rosely S.
[3, 4]
;
Menezes, Maria J.
[1]
;
D'Arcadia, Rosane R.
[1]
;
Komatsu, Natalia T.
[1]
;
Scopel, Kezia K. G.
[5, 1]
;
Braga, Erika M.
[5]
;
Cavasini, Carlos E.
[6]
;
Cordeiro, Jose A.
[7]
;
Ferreira, Marcelo U.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Acre, Ctr Ciencias Saude & Desporto, Rio Branco, AC - Brazil
[3] Inst Med Trop Sao Paulo, Lab Protozool, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Dept Doencas Infecciosas & Parasitarias, Sao Paulo - Brazil
[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, Belo Horizonte, MG - Brazil
[6] Fac Med Sao Jose do Rio Preto, Dept Doencas Dermatol Infecciosas & Parasitarias, Sao Jose Do Rio Preto, SP - Brazil
[7] Fac Med Sao Jose do Rio Preto, Dept Epidemiol & Saude Colet, Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Transactions of the Royal Society of Tropical Medicine and Hygiene; v. 104, n. 5, p. 343-350, MAY 2010. |
| Web of Science Citations: | 37 |
| Abstract | |
We describe the epidemiology of malaria in a frontier agricultural settlement in Brazilian Amazonia. We analysed the incidence of slide-confirmed symptomatic infections diagnosed between 2001 and 2006 in a cohort of 531 individuals (2281.53 person-years of follow-up) and parasite prevalence data derived from four cross-sectional surveys. Overall, the incidence rates of Plasmodium vivax and P. falciparaum were 20.6/100 and 6.8/100 person-years at risk, respectively, with a marked decline in the incidence of both species (81.4 and 56.8%, respectively) observed between 2001 and 2006. PCR revealed 5.4-fold more infections than conventional microscopy in population-wide cross-sectional surveys carried out between 2004 and 2006 (average prevalence, 11.3 vs. 2.0%). Only 27.2% of PCR-positive (but 73.3% of slide-positive) individuals had symptoms when enrolled, indicating that asymptomatic carriage of low-grade parasitaemias is a common phenomenon in frontier settlements. A circular cluster comprising 22.3% of the households, all situated in the area of most recent occupation, comprised 69.1% of all malaria infections diagnosed during the follow-up, with malaria incidence decreasing exponentially with distance from the cluster centre. By targeting one-quarter of the households, with selective indoor spraying or other house-protection measures, malaria incidence could be reduced by more than two-thirds in this community. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. (AU) | |