Expression of genes related to muscle plasticity after strength and power training regimens

Author(s)

Lamas, L. ^[1] ; Aoki, M. S. ^[2] ; Ugrinowitsch, C. ^[1] ; Campos, G. E. R. ^[3] ; Regazzini, M. ^[1] ; Moriscot, A. S. ^[4] ; Tricoli, V. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508030 Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, BR-05508030 Sao Paulo - Brazil

• Document type: Journal article
• Source: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 20, n. 2, p. 216-225, APR 2010.
• Web of Science Citations: 21

Abstract

The purpose of our study was to compare the effects of 8-week progressive strength and power training regimens on strength gains and muscle plasticity {[}muscle fiber hypertrophy and phenotype shift, mammalian target of rapamycin (mTOR), regulatory-associated protein of mTOR (RAPTOR), rapamycin-insensitive companion of m-TOR (RICTOR), calcineurin and calcipressin gene expression]. Twenty-nine physically active subjects were divided into three groups: strength training (ST), power training (PT) and control (C). Squat 1 RM and muscle biopsies were obtained before and after the training period. Strength increased similarly for both ST and PT groups (P < 0.001). Fiber types I, IIa and IIb presented hypertrophy main time effect (P < 0.05). Only type IIb percentage decreased from pre- to post-test (main time effect, P < 0.05). mTOR and RICTOR mRNA expression increased similarly from pre- to post-test (P < 0.01). RAPTOR increased after training for both groups (P < 0.0001), but to a greater extent in the ST (P < 0.001) than in the PT group. 4EBP-1 decreased after training when the ST and PT groups were pooled (P < 0.05). Calcineurin levels did not change after training, while calcipressin increased similarly from pre- to post-test (P < 0.01). In conclusion, our data indicate that these training regimens produce similar performance improvements; however, there was a trend toward greater hypertrophy-related gene expression and muscle fiber hypertrophy in the ST group. (AU)

• FAPESP's process: 06/00302-3 - Strength training with vibration: analysis of the determinant factors of vertical jump performance improvement
• Grantee: Carlos Ugrinowitsch
• Support Opportunities: Regular Research Grants