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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 3(2) Factorial Design

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Author(s):
Trossini, Gustavo H. G. [1] ; Giarolla, Jeanine [1] ; de Rezende, Leandro [2] ; do Amaral, Antonia T. [2] ; Zaim, Marcio H. [1] ; Bruns, Roy E. [3] ; Ferreira, Elizabeth I. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Pharm, Fac Pharmaceut Sci, BR-05508800 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-05508800 Sao Paulo - Brazil
[3] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Letters in Organic Chemistry; v. 7, n. 3, p. 191-195, APR 2010.
Web of Science Citations: 6
Abstract

Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 3(2) factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K(2)CO(3)) ratio. (AU)

FAPESP's process: 01/01192-3 - Potential antitripanosomal derived from nitro-heterocyclic compounds
Grantee:Elizabeth Igne Ferreira
Support Opportunities: Research Projects - Thematic Grants