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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of Full-Length Human Immunodeficiency Virus Type 1 Genome Reveals a Variable Spectrum of Subtypes B and F Recombinants in São Paulo, Brazil

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Author(s):
Sa Filho, Dercy José de [1] ; Sanabani, Sabri ; Diaz, Ricardo Sobhie ; Munerato, Patrícia ; Brunstein, Adriana ; Fusuma, Erika ; Sabino, Ester Cerdeira ; Janini, Luiz Mario
Total Authors: 8
Affiliation:
[1] Universidade Federal de São Paulo (UNIFESP). Escola Paulista de Medicina. Departamento de Medicina - Brasil
Total Affiliations: 8
Document type: Journal article
Source: AIDS Research and Human Retroviruses; v. 21, n. 2, p. 145-151, Feb. 2005.
Field of knowledge: Health Sciences - Medicine
Abstract

Recombination is one of the major mechanisms contributing to human immunodeficiency virus type 1 (HIV-1) variability. Analysis of pol gene sequences of 215 HIV-1 samples from São Paulo, Brazil classified 189 sequences as subtype B (87.9%), 8 sequences as subtype F (3.7%), and 18 sequences (8.4%) as B/F recombinants. After the analysis of the pol gene, a subset of six recombinant samples composed of sequences with a related recombinant pol structure was selected for full-length genome analysis to identify a possible circulating recombinant form. According to full-length genome analysis, recombination was higher in gag, protease, reverse transcriptase, integrase, and vif. Identification of many distinct recombinant forms and the absence of an identifiable HIV-1 circulating recombinant form suggest that a high frequency of dual infections between HIV-1 subtypes B and F is occurring in São Paulo, Brazil. (AU)