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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prenatal Lipopolysaccharide Reduces Social Behavior in Male Offspring

Full text
Author(s):
Kirsten, Thiago B. [1] ; Taricano, Marina [1] ; Maiorka, Paulo C. [1] ; Palermo-Neto, Joao [1] ; Bernardi, Maria M. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Pathol, Sch Vet Med, Neuroimmunomodulat Res Grp, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NEUROIMMUNOMODULATION; v. 17, n. 4, p. 240-251, 2010.
Web of Science Citations: 55
Abstract

Objective: This study investigated the relationship between maternal sickness behavior during pregnancy and offspring development and behavior. Methods: Pregnant Wistar rats were administered with lipopolysaccharide (LPS, 100 mu g/kg, i.p.) on gestation day (GD) 9.5. Dams' sickness behavior was analyzed, and at birth, offspring number and weight were evaluated. Male offspring was evaluated through physical development, play behavior, adult social interaction, plus maze studies and morphological analysis of the brain. Results: Results, with respect to the control group, showed that: (1) LPS decreased general activity, food intake, and weight gain in dams, but no pyrexia was observed following treatment; (2) LPS reduced litter size, but no alterations in physical development were observed; (3) LPS reduced play behavior parameters in baby rats; (4) LPS decreased adult social interaction; (5) no alterations were observed between groups on plus maze studies; (6) no differences were observed between groups on morphological analyses of the brain. Conclusion: These data reveal that LPS administered on GD 9.5 impaired male offspring's social behavior in infancy and adulthood. These results may be related to an alteration in motivational states or/and increased anxiety. Copyright (C) 2010 S. Karger AG, Basel (AU)

FAPESP's process: 06/54587-9 - Effects of prenatal administration of LPS on the dopaminergic and serotonergic central systems of male rat offspring
Grantee:Thiago Berti Kirsten
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 04/14128-0 - Neuroimmunomodulation: effects of drugs, stress and cytocines on central nervous and immune systems bidirectional relationships
Grantee:João Palermo Neto
Support Opportunities: Research Projects - Thematic Grants