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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Grade II atypical choroid plexus papilloma with normal karyotype

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Author(s):
Brassesco, Maria Sol [1, 2] ; Valera, Elvis Terci [1] ; Becker, Aline Paixao [3] ; Oliveira, Ricardo Santos [4] ; Scrideli, Carlos Alberto [1] ; Machado, Helio Rubens [4] ; Tone, Luiz Gonzaga [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Div Pediat Oncol, Dept Pediat, Fac Med Ribeirao Preto, Sao Paulo - Brazil
[2] USP, Hosp Clin, Fac Med Ribeirao Preto, Pediat Lab, BR-14048900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, Sao Paulo - Brazil
[4] Univ Sao Paulo, Div Neurosurg, Fac Med Ribeirao Preto, Dept Surg & Anat, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CHILD'S NERVOUS SYSTEM; v. 25, n. 12, p. 1623-1626, DEC 2009.
Web of Science Citations: 4
Abstract

Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. In the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed. CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome hybridization (CGH). Conventional karyotype analysis of tumor culture showed a normal chromosome complement. The results were confirmed by CGH, showing normal hybridization patterns for the sample. To date, the few atypical CPPs described in the literature have shown disparate cytogenetic information. This is the first report of a normal chromosome complement in atypical CPP. The heterogenic genetic features observed in these small series may reflect the diverse genetic background of choroid plexus tumors in children. (AU)