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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy

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Marcaccini, Andrea M. [1] ; Novaes, Jr., Arthur B. [1] ; Meschiari, Cesar A. ; Souza, Sergio L. [1] ; Palioto, Daniela B. [1] ; Sorgi, Carlos A. [2] ; Faccioli, Lucia H. [2] ; Tanus-Santos, Jose E. [3] ; Gerlach, Raquel F. [4]
Total Authors: 9
[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Buccomaxillofacial Surg & Periodontol, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14040904 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Dept Morfol Estomatol & Fisiol, Sch Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Clinica Chimica Acta; v. 409, n. 1-2, p. 117-122, NOV 3 2009.
Web of Science Citations: 47

Background: Periodontal disease shares risk factors with cardiovascular diseases and other systemic inflammatory diseases. The present study was designed to assess the circulating matrix metalloproteinases (MMPs) from chronic periodontal disease patients and, subsequently, after periodontal therapy. Methods: We compared the plasma concentrations of MMP-2. MMP-3, MMP-8, MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2, and total gelatinolytic activity in patients with periodontal disease (n =28) with those of control subjects (n = 22) before and 3 months after non-surgical periodontal therapy. Results: Higher plasma MMP-3, MMP-8, and MMP-9 concentrations were found in periodontal disease patients compared with healthy controls (all P<0.05), whereas MMP-2, TIMP-1, and TIMP-2 levels were not different. Treatment decreased plasma MMP-8 and MMP-9 concentrations by 35% and 39%, respectively (both P<0.02), while no changes were found in controls. MMP-2, MMP-3, TIMP-1, and TIMP-2 remained unaltered in both groups. Plasma gelatinolytic activity was higher in periodontal disease patients compared with controls (P<0.001) and decreased after periodontal therapy (P<0.05). Conclusions: This study showed increased circulating MMP-8 and MMP-9 levels and proteolytic activity in periodontal disease patients that decrease after periodontal therapy. The effects of periodontal therapy suggest that it may attenuate inflammatory chronic diseases. (C) 2009 Published by Elsevier B.V. (AU)