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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral distribution of Candida species and presence of oral lesions in Brazilian leprosy patients under multidrug therapy

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Author(s):
Ferraz de Araujo Navas, Edna Aparecida [1] ; Inocencio, Aline Cassia [1] ; Almeida, Janete Dias ; Back-Brito, Graziella Nuernberg [1] ; Mota, Adolfo Jose [2] ; Cardoso Jorge, Antonio Olavo [1] ; Rodrigues Querido, Silvia Maria [1] ; Balducci, Ivan ; Koga-Ito, Cristiane Yumi [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, Sao Jose Campos Dent Sch, Sao Paulo State Univ, Microbiol Lab, Dept Biosci & Oral Diag, BR-12245000 Sao Paulo - Brazil
[2] Vale Paraiba Univ UNIVAP, Genet Lab, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 38, n. 10, p. 764-767, NOV 2009.
Web of Science Citations: 7
Abstract

Objective: The aim of this study was to evaluate the prevalence of Candida spp. and presence of oral lesions in Brazilian leprosy patients under multidrug therapy (MDT). Methods: Thirty-eight individuals (18 males and 20 females, median age 53 years) clinically and microbiologically diagnosed as leprosy (lepromatous variant), and under MDT for at least 45 days were studied. The control group constituted by 38 healthy individuals (median age 53.5), matched to the test group in relation to age, gender and oral conditions. Oral rinses were collected and the Candida identification was performed by phenotypic tests. The existence of Candida dubliniensis among the isolates was analyzed using a validated multiplex PCR assay. Twenty-nine leprosy patients were examined intra-orally for the presence of lesions. Data were analyzed by z- and Mann-Whitney tests (alpha = 5%). Results: Yeast carriage rate between leprosy patients (65.8%) and controls (47.4%) was similar (P = 0.099), and no significant difference between yeast counts was observed (P = 0.1004). Candida albicans was the most frequently isolated species in both groups. In the leprosy group, Candida tropicalis and Candida parapsilosis were also identified. In the control group, we additionally identified Candida tropicalis, Candida glabrata and Candida kefyr. Candida dubliniensis was not detected. No leprosy-related oral lesion was registered. Conclusion: Within the limits of the study, we concluded that Brazilian leprosy patients under MDT showed similar levels of carriage and Candida species distribution in relation to the controls. (AU)